Successful management of retinal metastasis from renal cancer with everolimus in a monophthalmic patient: a case report

Abstract

BackgroundThe retina is an uncommon site for metastases, in particular from solid tumors. Some authors have reported a recent increase in the incidence of metastases in infrequent sites, such as brain or bone, probably due to the expanded treatment options and the resulting improved survival. Choroidal metastasis is the most common type of intraocular malignancy. The most common primary sites associated with choroidal metastasis are breast cancer in women and lung cancer in men. Treatment options are limited, but they must be discussed and adapted to the patient profile.Cases presentationWe report a case of a 62-year-old Moroccan man with a history of monophthalmitis secondary to a war injury of 30 years’ duration. He has been followed for 28 months for metastatic clear-cell renal carcinoma. The first-line treatment was effective for 24 months, before disease progression as retinal metastasis and accentuation of lung metastases. A second-line treatment with everolimus resulted in marked improvement of symptoms, complete recovery of visual function, and partial response in retinal localization.ConclusionsChoroidal metastasis of renal cancer is a rare situation that must be actively sought in order to arrive at a suitable therapeutic approach.

Reconsidering the central role of mucins in dry eye and ocular surface diseases

“…Essadi et al reported a case of a CM from clear-cell renal carcinoma successfully treated by everolimus alone (an inhibitor of mammalian target of rapamycin, mTOR,) as second-line systemic treatment (the patient also had lung metastases). The patient had complete recovery of vision at 4 months and partial response as assessed by tumor size 44 (Essadi et al, 2017). In CM from prostate cancer, some case reports have shown the effectiveness of hormonal blockade monotherapy (Primavera et al, 2008).…”

Risk factors for intraocular metastasis of primary liver cancer in diabetic patients: Alpha-fetoprotein and cancer antigen 125

“…To date, carcinoma-related IOM has been reported in patients with rectal cancer[ 14 ], lung cancer[ 15 ], breast cancer[ 16 ], esophageal carcinoma[ 17 ], thyroid cancer[ 18 ], gastric carcinoma[ 19 ], renal cancer[ 20 ], and choriocarcinoma[ 21 ] (Table 5 ).…”

Serum markers change for intraocular metastasis in renal cell carcinoma

“…The choroid is the most common site of IOM in malignant tumors. The most common primary cancers with choroidal metastasis are female breast cancer and male lung cancer [ 13 ]. In the metastatic tumors of the eye, they were mainly located in three locations: 73.6% of the patients were involved in the eyes, 12.3% were involved in the orbit and 14.1% were involved in the eyes and the orbit.…”