2013
DOI: 10.1111/trf.12331
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Successful management of severe hemolytic disease of the fetus due to anti‐Jsb using intrauterine transfusions with serial maternal blood donations: a case report and a review of the literature

Abstract: This case represents a successful example of managing hemolytic disease of the fetus due to a rare antibody using maternal blood. It also supports previous data on safety of maternal donations during pregnancy and the use of combination of rHu-EPO and IV-Fe as a supportive measure.

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Cited by 16 publications
(10 citation statements)
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“…18 A saline wash was used for the processed RBC units of one previously reported patient with HDFN due to the presence of anti-Js b antibodies; in this case, the mother had donated blood while pregnant due to the low likelihood of finding a suitable donor. 19 All RBC units were quality-checked for final volume measurements, Hct proportion and residual WBC counts. After testing to determine the ABO blood group, the donor samples were additionally screened for Rh (C, c, E and e) and K antigens, the sickle cell trait and glucose-6-phosphate dehydrogenase deficiency.…”
Section: Intrauterine Fetal Blood Transfusionmentioning
confidence: 99%
“…18 A saline wash was used for the processed RBC units of one previously reported patient with HDFN due to the presence of anti-Js b antibodies; in this case, the mother had donated blood while pregnant due to the low likelihood of finding a suitable donor. 19 All RBC units were quality-checked for final volume measurements, Hct proportion and residual WBC counts. After testing to determine the ABO blood group, the donor samples were additionally screened for Rh (C, c, E and e) and K antigens, the sickle cell trait and glucose-6-phosphate dehydrogenase deficiency.…”
Section: Intrauterine Fetal Blood Transfusionmentioning
confidence: 99%
“…Where detected, antibodies to other antigens in the Kell blood group system (e.g. anti‐k, ‐Kp a , ‐Kp b , ‐Js a , ‐Js b ) should be investigated and monitored in the same way as anti‐K as these have the potential to cause HDFN (Al Riyami et al, ).…”
Section: Red Cell Antibodies Detected In Pregnancymentioning
confidence: 99%
“…However, when multiple maternal blood donations for IUT are needed, it is necessary to advise iron and folic acid supplementation. Serial maternal donations can be successfully managed by recombinant human erythropoietin and intravenous iron [25]. Washed maternal RBCs are safe for fetal transfusion therapy, even when they are ABO incompatible, because the fetus does not have its own anti-A and anti-B antibodies, so maternal RBCs cannot be hemolyzed [15].…”
Section: Discussionmentioning
confidence: 99%