Successful management with interferon alpha‐2a after prednisone therapy failure in an infant with a giant cavernous hemangioma

Castello, Manuel A.; G, Ragni; Antimi, A.; Ar, Todini; Patti, Gianluca; Lubrano, Riccardo; Clerico, A.; Calisti, Alessandro

doi:10.1002/(sici)1096-911x(199703)28:3<213::aid-mpo12>3.3.co;2-m

Cited by 4 publications

(5 citation statements)

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“…Interferon-α-2a and interferon-α-2b have gained recent attention for the treatment of hemangiomas. [93][94][95][96][97][98][99][100][101][102][103][104][105] Interferon-α-2a was initially conceived as an antiviral agent. During the course of clinical trials in patients with AIDS, regression of Kaposi sarcoma lesions was observed in treated patients.…”

Section: Managementmentioning

confidence: 99%

“…95 Treatment of hemangiomas with interferon-α-2a or α-2b has generally been reserved for those lesions that are believed to be life-threatening or possibly causing function-impairing sequelae or severe cervicofacial disfigurement. [93][94][95][96][97][98][99][100][101][102][103][104][105] It has been particularly used for those lesions that appear to be resistant to corticosteroids. The usual starting dosage is 1 million units given subcutaneously nightly.…”

Section: Managementmentioning

confidence: 99%

See 1 more Smart Citation

Hemangiomas: An Overview

Sundine

Wirth

2007

Clin Pediatr (Phila)

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Hemangiomas are the most common tumors of infancy 2 and are also the most common tumors of the head and neck in infancy. 3 The incidence of hemangiomas in the first 3 days of life is 1.1% to 2.6% 4,5 and increases to 8.7% to 12.7% between the ages of 1 month and 1 year of life. [6][7][8] Amir et al 8 found that the incidence of hemangiomas increased with prematurity. In infants with birth weights of less than 1500 grams, the incidence of hemangiomas was 15.6%, and as the birth weight decreased below 1000 grams, the incidence of hemangiomas increased to 22.9%. Holmdahl 9 did not observe any difference in the incidence of hemangiomas between premature and mature infants; however, a review of his study shows that the birth weights of the infants were much greater than those of Amir et al. 8 A review of 830 patients examined by a single pediatric dermatologist during a 3-month period found vascular lesions to be the most common, with 44% of infants having these lesions. 10 Hemangiomas are more frequent in girls than boys, ranging from a 3:1 to 5:1 ratio. [11][12][13] They are thought to be more common in white patients than in blacks; however, Pratt 4 noted an 1% incidence of hemangiomas in black infants. Most series show an increased incidence of hemangiomas in the head and neck region, followed by the trunk and then the extremities. 12,14 The incidence of hemangiomas in infants whose mothers underwent chorionic villus sampling is 10 times greater than those infants whose mothers did not undergo the procedure. 15 Approximately 20% of infants will present with more than 1 lesion. 16 Most hemangiomas occur sporadically; however, a family history of hemangioma has been noted to be present in up to 10% of patients with hemangiomas. 12 Recently, Blei et al 17 were able to identify 6 families that demonstrated autosomal dominant transmission with moderate-to-high penetrance of hemangiomas. The female-male ratio was 2:1,

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Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Hemangiomas: An Overview

Sundine

Wirth

2007

Clin Pediatr (Phila)

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“…Disseminated intravascular coagulation can often be controlled with heparin or low-molecular-weight heparin, usually delivered subcutaneously, or antithrombin, c~r~c~ntr~te; however, occasionally local radiation therapy or injections of sclcrosing agents have been reported to be beneficial (4,97,99). Of particular interest are recent reports of the efficacy of alpha interferon in treating the Kasabach-Merritt syndrome (100,101). Also, patients may develop localized but extensive deep vein thrombosis in association with giant cavernous hemangiomata (102).…”

Section: Pseudoxanthoma Elasticummentioning

confidence: 99%

State-of-the-Art Review: Vascular Thrombohemorrhagic Disorders: Hereditary and Acquired

Bick¹

2001

Clin Appl Thromb Hemost

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This review has summarized the more important diseases that may be accompanied by or lead to a disorder of hemostasis or thrombosis via alterations of the vasculature. It is to be stressed that the vascular component of hemostasis is often overlooked by clinicians caring for patients with disorders of hemostasis and thrombosis. It should be appreciated that the vasculature is intricately related to the coagulation protein system and to platelets when involved in thrombohemorrhagic diatheses. Although many vascular disorders may lead to hemorrhage or thrombosis, it must be appreciated that often it is impossible to discern between a primary vascular defect/damage and a defect that has been induced by platelet activation/dysfunction or procoagulant abnormalities.

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“…Interferon-a (IFN-a) has shown promise in the treatment of vascular lesions (21)(22)(23)(24). This agent is reported to inhibit endothelial cell proliferation and angiogenesis.…”

Section: Discussionmentioning

confidence: 99%