Successful medical management of a 16-month chronic type A aortic dissection

Mo, Alan; Cha, Jin-whan; Yang, Millet

doi:10.1016/j.radcr.2020.03.007

Cited by 1 publication

(2 citation statements)

References 10 publications

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“…Aortic dissection (AD) is one of the most frequent types of aortic disease with extremely poor prognosis . In AD, the aortic wall is dissected due to a tear in the intima of the aorta or bleeding within it . Emergency surgical repair is the current recommended treatment option for AD.…”

Section: Introductionmentioning

confidence: 99%

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Stimulus-Responsive Zwitterionic Prodrug Delivery System with Sustained Release of Hydrogen Sulfide for Protective Aortic Dissection

Ren

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Aortic dissection (AD) is one of the most frequent types of aortic disease with extremely poor prognosis. The biological signaling gas hydrogen sulfide (H2S) has exhibited protective effects in various types of cardiovascular diseases. However, as a toxic, colorless gas, the application of H2S is immensely hampered due to the lack of ideal donors. In this article, a drug delivery system with a H2S donor has been prepared. Meanwhile, the donor could be deposed in a cysteine-containing environment to generate H2S. The results indicate that the H2S donor polymer nanomicelles mitigated the processive transformation of smooth muscle cells effectively in a proper concentration range, which may play a protective role in aortic dissection. In animal experiments, the sustained-release H2S donor stimulated in the presence of cysteine was found to demonstrate beneficial effects in a murine model of aortic dissection and would likely become a potential target of H2S therapy for cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

“…1 In AD, the aortic wall is dissected due to a tear in the intima of the aorta or bleeding within it. 2 Emergency surgical repair is the current recommended treatment option for AD. Unfortunately, mortality for AD is still as high as 1% per hour.…”

Section: Introductionmentioning

confidence: 99%

Stimulus-Responsive Zwitterionic Prodrug Delivery System with Sustained Release of Hydrogen Sulfide for Protective Aortic Dissection

Ren

Liu

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

Successful medical management of a 16-month chronic type A aortic dissection

Cited by 1 publication

References 10 publications

Stimulus-Responsive Zwitterionic Prodrug Delivery System with Sustained Release of Hydrogen Sulfide for Protective Aortic Dissection

Stimulus-Responsive Zwitterionic Prodrug Delivery System with Sustained Release of Hydrogen Sulfide for Protective Aortic Dissection

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