Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenström's macroglobulinemia with severe pancytopenia

Abstract

Summary:We report a 62-year-old male who underwent non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) because of his life-threatening severe pancytopenia due to refractory Waldenström's macroglobulinemia. This therapy was performed safely and he made a marked recovery from his cytopenia that had not been improved with any other therapy. Bone marrow aspirates showed post-transplant mixed chimerism during engraftment, and became completely donor-derived after a series of GVHD symptoms, without subsequent donor lymphocyte infusion. Our results suggest that non-myeloablative allogeneic PBSCT could be a good alternative for patients suffering from multidrug resistant Waldenström's macroglobulinemia. Bone Marrow Transplantation (2001) 28, 609-611.

Evidence of graft-versus-Waldenstrom's macroglobulinaemia effect after allogeneic stem cell transplantation: a single centre experience

“…18,[20][21][22] A graft-versus-WM effect has previously been suggested. 3,23 Similar to the case report by Ueda et al, 23 in which a reduction in abnormal cell counts in bone marrow and the disappearance of abnormal phenotypic cells occurred after a series of GVHD, as is shown in Figure 1, symptoms of GVHD temporally correlate with decreases in monoclonal protein values. Only one patient received steroids for treatment of the GVHD.…”

Allogeneic hematopoietic stem cell transplantation allows long-term complete remission and curability in high-risk Waldenstrom's macroglobulinemia. Results of a retrospective analysis of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire

“…3,4 Allogeneic stem cell transplantation may improve tumor response due to graft-versus-tumor effect. [5][6][7][8][9][10][11] We have previously obtained encouraging results with allogeneic stem cell transplantation in a series of 10 patients. 4 Here we report longer follow-up of these 10 patients along with data on 15 additional cases.…”

Waldenström macroglobulinemia: A review of therapy

“…A 52-yearold man who had a nonmyeloablative allogeneic transplantation had a marked recovery from his cytopenia. Post-transplantation, his bone marrow showed mixed chimerism that became completely donor derived after the development of graft-versus-host disease [84].…”