Successful pregnancy after chemo‐immuno‐radiation therapy for aggressive lymphoma of the uterus

Abstract

immortalization-specific signature and a leukaemic subtypespecific signature (common to cell lines and primary leukaemias bearing identical genetic rearrangements) are superimposed in the gene expression profiles of leukaemic cell lines. The immortalization-specific signature detected in leukaemic cell lines involves a large number of genes and large changes in expression, effectively dominating the leukaemic subtype-specific signatures. Alexandre

Primary lymphoma of the uterus and cervix: two case reports and review of the literature

“…14, 15 Ferreri et al reported a 29-year-old woman who was treated with R-CHOP and underwent ovarian transposition before involved field radiotherapy. 18 The patient is relapse free at 54 months and has a 9-month-old child. To preserve reproductive function in young patients, combination chemotherapy alone has been advocated in some case reports.…”

Successful Vaginal Delivery after Induction of Labour in a Patient Treated for Non-Hodgkin’s Lymphoma of the Cervix: A Case Report and Literature Review

“…Among subtypes, large B-cell is the most common non-Hodgkin's lymphoma of the cervix, representing approximately 31% of cases [ 10 ]. Affected women usually present with symptoms such as abnormal vaginal bleeding, dyspareunia, and/or pelvic pain, whereas for fever, night sweats, and weight loss, traditional lymphoma symptoms are uncommon [ 4 – 7 ]. The appropriate management starts with a cervical biopsy with pathological immune-phonotypical evaluation, to differentiate cervical non-Hodgkin's lymphoma from benign and malignant disease of the cervix.…”

“…There is occurrence of potential complications such as pelvic outlet obstruction or potential lower uterine segment rupture (due to incomplete resolution of the disease or architectural changes after radiations, let the mode of delivery become an argument of discussion) [ 4 – 8 ]. Indeed, the available literature regarding the mode of delivery for patient affected by a cervical lymphoma reports that only two out of the five previously reported cases experienced a successfully vaginal delivery [ 7 , 8 ]. One out of three cases delivered via caesarean section received a specific indication due to the previously treated cervical lymphoma [ 6 ].…”

“…All but one pregnancy occurred at least two years after resolution of the disease, and only one has been diagnosed during pregnancy [ 5 ]. Almost all cases have been treated with chemotherapy (4/5), one out of five also received a surgical treatment (cold knife conization) [ 6 ], and one also received radiotherapy [ 7 ]. No delivery complications have been reported.…”

Fertility preservation with successful pregnancy outcome in a patient with transplanted heart and non-Hodgkin’s lymphoma – a case report

“…First pregnancy after chemo-immuno-radiation therapy for a pelvic lymphoma was described in 2008, Ferreri et al described a spontaneous pregnancy with a vaginal delivery of a healthy baby 36 months after pelvic radiotherapy [9]. The therapeutic strategy was similar, but in a lower dose (6 versus 8 cycles of R-CHOP and 30-6Gy versus 36Gy of radiotherapy).…”