Successful pregnancy in a neurologically impaired woman with Wilson's disease

Berghella, Vincenzo; Steele, D. P.; Spector, Toba; Cambi, Franca; Johnson, Anthony

doi:10.1016/s0002-9378(97)70577-5

Cited by 24 publications

(16 citation statements)

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“…It is hence imperative that it is identified early and treated effectively. Safety of Pencillamine in managing Wilson’s disease during pregnancy has been reported by multiple studies [4-6,8]. Only one case report states an infant developing connective tissue disorder in a mother with a daily intake of 2 grams of pencillamine which is approximately twice the dose used for Wilson’s disease in pregnancy [12].…”

Section: Discussionmentioning

confidence: 99%

Wilson’s disease in pregnancy: case series and review of literature

2013

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BackgroundWilson’s disease is a rare, autosomal recessive inherited disorder characterized by impaired liver metabolism of copper leading to decreased biliary excretion and incorporation of ceruloplasmin levels mainly in the liver and brain. Untreated Wilson’s disease has been shown to cause subfertility and even in cases where pregnancy occurs, it often results in spontaneous miscarriage.Case presentationsWe present four cases of successful pregnancy outcomes in three patients diagnosed with Wilson’s disease along with the literature review. All the patients were managed with zinc sulphate without any postnatal complications.ConclusionPatients with Wilson’s disease receiving regular treatment who remain asymptomatic are usually able to conceive and achieve successful outcomes. However, these pregnancies should be considered high risk and merit regular surveillance.

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Section: Discussionmentioning

confidence: 99%

Wilson’s disease in pregnancy: case series and review of literature

2013

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“…Despite these facts it seems that patients who receive proper treatment may be able to conceive and reach a favorable outcome of pregnancy [1,4,8]. …”

Section: Discussionmentioning

confidence: 99%

“…Since the first documentation of its effectiveness [9], penicillamine has been regularly used to keep pregnant women asymptomatic. The dosage of 500 mg/day proves to be almost harmless to the fetus and quite effective at the same time for the treatment of the disease [5,7,8], although the dosage depends basically on the individual data of the patient and the stage of the copper-intoxication. Despite these studies, proper counseling should always be offered to pregnant women and their families regarding birth defects caused by penicillamine in larger doses, such as cutis laxa like syndrome, micrognathia, low-set ears, hyperflexibility of joints, fragile veins, varicosity and impaired wound healing [10].…”

Section: Discussionmentioning

confidence: 99%

Placenta abruption in a woman with Wilson's disease: a case report

Theodoridis

Zepiridis

Athanatos

et al. 2009

Cases J

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Wilson’s disease is a rare genetic disorder of copper metabolism that causes primary hepatic cirrhosis, secondary menstrual abnormalities and infertility. Following the appropriate therapy patients are asymptomatic and pregnancy may be achieved. We present a case of placental abruption in a pregnant woman with Wilson’s disease and we review the management dilemmas and treatment options of pregnant women with Wilson’s disease.

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“…Bu hastalarda, kronik karaciğer hastalığı ve endokrin bozuklukların yaygın olması bu durumu açıklayabilir. Bu gerçeklere rağmen, uygun tedavi alan ve gebelik öncesi ve sırasında yakın takip ile izlenen hastalarda olumlu gebelik sonuçlarına ulaşmak mümkün olabilir gibi görünmektedir (11)(12)(13)(14).…”

Section: Discussionunclassified