Successful prevention of preeclampsia in a high-risk pregnancy using progestogen dydrogesterone: a clinical case

Tskhay, V.B.; Kovtun, Natalya M; Schindler, A. E.

doi:10.1515/hmbci-2016-0019

Cited by 6 publications

(3 citation statements)

References 16 publications

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“…P4 is an essential hormone in the process of reproduction, and circulating P4 is significantly lower in PE women compared to controls [16]. There are pieces of evidence that early P4 treatment in ART improves the incidence and outcome of pre-eclampsia [50][51][52]. In addition, animal experiments also demonstrated that P4 could attenuate hypertension, improve inflammation, and boost fetal weight in a reduced uterine perfusion pressure rat model [16,17,53].…”

Section: Discussionmentioning

confidence: 99%

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

et al. 2022

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Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a class III histone deacetylase, is associated with the regulation of various pathophysiological processes, including inflammation, immune response, metabolism, and autophagy. However, the effect of SIRT1 in the pathogenesis of pre-eclampsia remains to be elucidated. In this study, we found that the expression of SIRT1 was relatively lower in the placentas and serum samples of pre-eclampsia patients. Typical pre-eclampsia-like symptoms, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and a narrow placental labyrinth layer, were observed in SIRT1 knockdown (SIRT1+/−) mice. Of note, these performances could be improved after the intraperitoneal injection of SIRT1 agonist SRT2104. More importantly, we found that the efficacy of progesterone on attenuating symptoms of PE was profoundly better than that of metformin in SIRT1+/− mice. In addition, our results suggested that progesterone can promote the invasion and inhibit the apoptosis of trophoblasts. These data suggest that SIRT1 plays an important role in pre-eclampsia and that progesterone alleviates pre-eclampsia-like symptoms mediated by SIRT1 deficiency.

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Section: Discussionmentioning

confidence: 99%

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

et al. 2022

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“…A favourable effect of dydrogesterone has also been reported for 30 mg dydrogesterone from early pregnancy until 37 th week of gestation in a high-risk woman for preeclampsia prevention [22].…”

Section: Prevention Of Preeclampsiamentioning

confidence: 75%

A brief guideline proposal for using dydrogesterone prevention or treatment of pregnancy disorders

Schindler¹

2017

J Pregnancy Reprod

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“…from early pregnancy until 37th weeks of gestation. The pregnancy was uneventful and delivery was done by repeat Csection at 39th weeks of gestation with a fetal weight of 3750 g and a length of 53 cm [22].…”

Section: Recent Data On Dydrogesterone and Preeclampsiamentioning

confidence: 99%

New data about preeclampsia: some possibilities of prevention

Schindler¹

2018

Gynecological Endocrinology

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This concise report deals with the known effects of progestogen lack in early pregnancy with failure of implantation and blood supply to the placenta depending on proper trophoblast invasion, spiral artery remodeling, and vessel dilatation. The pathophysiology of preeclampsia will be outlined and the most recent data on the effect of dydrogesterone presented. Dydrogesterone appears to be able to reduce significantly the development of preeclampsia. The effect is related to begin with such prevention and this should be continued until 37th weeks of gestation which would also mean prevention of premature labor.

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Successful prevention of preeclampsia in a high-risk pregnancy using progestogen dydrogesterone: a clinical case

Cited by 6 publications

References 16 publications

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

A brief guideline proposal for using dydrogesterone prevention or treatment of pregnancy disorders

New data about preeclampsia: some possibilities of prevention

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