Successful radiofrequency ablation of liver metastases from prostate cancer

Abstract

Introduction: Patients with liver metastases from prostate cancer show poor prognosis. We performed metastases-directed therapy using radiofrequency ablation of liver metastases in an attempt to improve the prognosis in a patient with metastatic prostate cancer. Case presentation: We present the case of a 66-year-old man who was treated for metastatic castration-resistant prostate cancer. Evaluation showed isolated liver metastases together with elevated serum prostate-specific antigen levels. We performed metastases-directed therapy using radiofrequency ablation of the liver tumor. The patient showed no recurrent liver metastases for 42 months and survived for 66 months after diagnosis of metastatic prostate cancer. Conclusion: To our knowledge, this is the first report that describes radiofrequency ablation of liver metastases from prostate cancer. This procedure may be a useful therapeutic option for metastases-directed therapy in patients with liver metastases from prostate cancer.

Prostate Cancer Liver Metastasis: An Ominous Metastatic Site in Need of Distinct Management Strategies

“…In one case study, a 77-year-old man with PCLM treated with a combination of stereotactic image-guided percutaneous microwave ablation and Olaparib sustained remission from LM [92]. Furthermore, in another case study, a 66-year-old man with PCLM treated with radiofrequency ablation to the liver had no LM recurrence for 42 months [93]. Additionally, Yeo et al showed the potential for microwave needle ablation and SBRT to target LM [94].…”