Successful re-administration of Pazopanib in a patient with metastatic renal cell carcinoma and a history of Pazopanib-induced nephrotic syndrome: a case report

Jeon, Soyeon; Lee, Na-Ri; Yim, Chang-Yeol

doi:10.1186/s12882-018-1181-1

Cited by 59 publications

(49 citation statements)

References 9 publications

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“… 31–40 Although the underlining mechanism is yet to be fully elucidated, previous epidemiological studies revealed that a lower level of handgrip strength was associated with all-cause mortality, 33–35 40 chronic diseases 39 and cardiovascular mortality. 38 40 However, we did not observe an association between handgrip strength and mortality in our study population. This may be due to the high level of handgrip strength among Olympic athletes.…”

Section: Discussioncontrasting

confidence: 72%

Mortality of Japanese Olympic athletes in 1964 Tokyo Olympic Games

Takeuchi

Kitamura

Ishizuka

et al. 2021

BMJ Open Sport Exerc Med

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ObjectivesTo compare the mortality of Japanese athletes in the 1964 Tokyo Olympic Games with that of the Japanese population, and to elucidate factors associated with their mortality.MethodsWe obtained from the Japan Sport Association study subjects’ biographical information, information on lifestyles and medical data. Missing data were obtained from online databases. Standardised mortality ratio (SMR) was calculated to compare athletes’ mortality with the Japanese population. Cox proportional hazards model was applied to estimate the HR for each category of body mass index (BMI), smoking history and handgrip strength. This analysis was limited to male athletes due to the small number of female athletes.ResultsAmong 342 (283 men, 59 women) athletes, deaths were confirmed for 70 (64 men, 6 women) athletes between September 1964 and December 2017. Total person years was 15 974.8, and the SMR was 0.64 (95% CI 0.50 to 0.81). Multivariate analysis performed on 181 male athletes. Mortality was significantly higher for BMI≥25 kg/m2 than for 21–23 kg/m2 (HR: 3.03, 95% CI 1.01 to 9.07). We found no statistically significant associations between smoking history and mortality; the HR (95% CI) for occasional and daily smokers were 0.82 (0.26 to 2.57) and 1.30 (0.55 to 3.03) compared with never smokers. We also found no statistically significant associations between handgrip strength and mortality (P for trend: 0.51).ConclusionJapanese athletes in the 1964 Tokyo Olympic Games lived longer than the Japanese population. BMI≥25 kg/m2 was associated with higher mortality, but smoking history and handgrip strength were not associated with mortality.

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Section: Discussioncontrasting

confidence: 72%

Mortality of Japanese Olympic athletes in 1964 Tokyo Olympic Games

Takeuchi

Kitamura

Ishizuka

et al. 2021

BMJ Open Sport Exerc Med

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“…Some studies also suggest that the localization of AVF in hemodialyzed patients may be associated with symptoms severity, which in turn influences the QOL [24]. These observations, however, were made in a cohort of dialyzed patients and it remains unclear whether they can be extrapolated from KTRs with persistent AVF.…”

Section: Plos Onementioning

confidence: 99%

The attitude of kidney transplant recipients towards elective arteriovenous fistula ligation

et al. 2020

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Background Arteriovenous fistulas (AVF) are a source of various complications. Among previously hemodialyzed kidney transplant recipients (KTxR), the AVF may persist over time. The patients' decisions whether to ligate the functioning AVF may be prompted by many factors. Our knowledge of benefits concerning the procedure as well as patients' attitude towards it is scarce. Aim Evaluation of the patients' opinion on the persistent AVF ligation after a successful kidney transplantation. Materials and methods An anonymous survey was carried out among 301 previously hemodialyzed KTxR. The patients were recruited during scheduled visits in the Transplantation Outpatient Unit. All subjects completed an anonymous questionnaire including questions about their attitude towards the matter in question. Results 69 patients (22.9%) have considered AVF closure. The most common causes for such attitude were esthetic reasons (n = 29) and concerns about heart health (n = 13). Among those 69 subjects, 18 have presented with symptomatic AVF due to multiple symptoms. Symptomatic AVFs were localized on the forearm in 14 out of 18 cases. As many as 116 (38.5%) cases have never wanted to ligate the AVF and 116 (38.5%) subjects did not have a clear opinion. In our study we report 158 (52.5%) cases of non-functioning AVFs. The main reason for the above was spontaneous AVF thrombosis (121 cases). Only 24 subjects reported to rely on the physician-provided information about the AVF management.

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“…The antihypertensive effects of propolis have been studied in different animal models (see Table 4 ) and have been attributed to several biological activities, including the modulation of vascular tone, anti-inflammatory and antioxidant [ 88 ].…”

Section: Cardiovascular Effects Of Propolismentioning

confidence: 99%

“…A double-blind, placebo-controlled study demonstrated that the administration of Beepolis ® (Laboratorio Rotterdam Ltda, San Javier, Chile), a 3% Chilean Propolis solution in propylene glycol, decreased BP in hypertensive patients over a period of 90 days [ 93 ]. However, in another double-blind, placebo-controlled study, the co-administration of Brazilian Green Propolis (500 mg/day) and antihypertensive drugs to patients with hypertension and chronic kidney disease showed no change in BP after a period of 12 months [ 88 ].…”

Section: Cardiovascular Effects Of Propolismentioning

confidence: 99%

The Cardiovascular Therapeutic Potential of Propolis—A Comprehensive Review

Silva

Francisco

Saraiva

et al. 2021

Biology

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Owing to its chemical richness, propolis has a myriad of therapeutic properties. To the authors’ knowledge, this is the first comprehensive review paper on propolis to focus exclusively on its major effects for cardiovascular health. The propolis compound varieties with the most promising therapeutic benefits and their respective physiological mechanisms will be discussed. Propolis displays an anti-atherosclerotic activity, attained through modulation of the plasma lipid profile and through stabilization of the fatty plaque by inhibiting macrophage apoptosis, vascular smooth muscle proliferation and metalloproteinase activity. The antihypertensive effects of propolis probably arise through the combination of several mechanisms, including the suppression of catecholamine synthesis, stimulation of endothelium-dependent vasorelaxation and vascular anti-inflammatory activity. The anti-hemostatic activity of propolis is attributed to the inhibition of platelet plug formation and antifibrinolytic activity. By inhibiting the secretion of proangiogenic factors, propolis suppresses endothelial cell migration and tubulogenesis, exerting antiangiogenic activity. The antioxidant and anti-inflammatory activities are responsible for protection against vascular endothelial and cardiomyocyte dysfunction, mostly by the prevention of oxidative stress. Among the reviewed propolis varieties, the Brazilian green and red varieties show the largest number of beneficial activities. Further research, especially preclinical, should be conducted to assess the cardiovascular benefits of the given varieties with different compositions.

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Successful re-administration of Pazopanib in a patient with metastatic renal cell carcinoma and a history of Pazopanib-induced nephrotic syndrome: a case report

Cited by 59 publications

References 9 publications

Mortality of Japanese Olympic athletes in 1964 Tokyo Olympic Games

Mortality of Japanese Olympic athletes in 1964 Tokyo Olympic Games

The attitude of kidney transplant recipients towards elective arteriovenous fistula ligation

The Cardiovascular Therapeutic Potential of Propolis—A Comprehensive Review

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