Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report

Ikuyama, Yuichi; Wada, Yosuke; Tateishi, Kazunari; Kitaguchi, Yoshiaki; Matsumura, Yasuo; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Kamijo, Hiroshi; Mita, Atsuyoshi; Imamura, Hiroshi; Hanaoka, Masayuki

doi:10.1016/j.rmcr.2020.101113

Cited by 7 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Venovenous ECMO might be useful in COVID-19 patients with severe ARDS ( 6 – 10 ), as previously described during past respiratory virus outbreaks ( 12 ). Here, we report the experience of our ICU of University hospital.…”

Section: Discussionmentioning

confidence: 85%

“…Implantation of ECMO occurred 13 [10][11][12][13][14][15][16][17][18][19][20][21][22] days after the onset of symptoms, 6 [3][4][5][6][7][8][9][10][11] days after the onset of mechanical ventilation and 6 [4][5][6][7][8][9][10][11] days after ICU admission. Four (36%) patients were secondary transferred in our ICU after ECMO implantation by the ECMO mobile team and one (9%) patient was initially supported with veno-arterial femoro-femoral ECMO for cardiac arrest due to pulmonary embolism, and thereafter supported with venovenous ECMO.…”

Section: Ecmo Managementmentioning

confidence: 99%

“…Most of these patients develop severe ARDS that require administration of neuromuscular blocking (NMB) agents and prone positioning (PP). In COVID-19 patients, venovenous extracorporeal membrane oxygenation (ECMO) has been described as suitable (6)(7)(8)(9)(10)(11), such as previously employed during past respiratory virus outbreaks (i.e., Middle East respiratory syndrome and H1N1) (12).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Use of Venovenous Extracorporeal Membrane Oxygenation in Critically-Ill Patients With COVID-19

et al. 2020

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) related to Coronavirus disease (COVID-19) is associated with high mortality. It has been suggested that venovenous extracorporeal membrane oxygenation (ECMO) was suitable in this indication, albeit the effects of ECMO on the mechanical respiratory parameters have been scarcely described. In this case-series, we prospectively described the use of venovenous ECMO and its effects on mechanical respiratory parameters in eleven COVID-19 patients with severe ARDS. Implantation of ECMO occurred 6 [3–11] days after the onset of mechanical ventilation. At the time of ECMO implantation, all patients received neuromuscular blocking agents, three (27%) received inhaled nitric oxide and prone positioning was performed in all patients with 4 [3−5] sessions of PP per patient. Under ECMO, the tidal volume was significantly decreased from 6.1 [4.0–6.3] to 3.4 [2.5–3.6] mL/kg of predicted body weight and the positive end-expiratory pressure level was increased by 25 ± 27% whereas the driving pressure and the mechanical power decreased by 33 ± 25% and 71 ± 27%, respectively. The PaO2/FiO2 ratio significantly increased from 68 [58–89] to 168 [137–218] and the oxygenation index significantly decreased from 28 [26–35] to 13 [10–15]. The duration of ECMO was 12 [8–25] days. Nine (82%) patients experienced ECMO-related complications and the main complication was major bleeding requiring blood transfusions. Intensive care unit mortality rate was 55% but no patient died from ECMO-related complications. In COVID-19 patients with severe ARDS, venovenous ECMO allowed ultra-protective ventilation, improved oxygenation and should be considered in highly selected patients with the most severe ARDS.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Ecmo Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of Venovenous Extracorporeal Membrane Oxygenation in Critically-Ill Patients With COVID-19

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Pemeriksaan laboratorium mengungkapkan limfopenia darah perifer (350/μL) dan peningkatan kadar urea nitrogen darah (BUN, 28,9 mg/dL), kreatinin (1,62 mg/dL), protein C-reaktif (CRP, 12,90 mg/dL), dan laktat dehidrogenase (LDH, 325 U/L). Gambar chest computed tomography (CT) menunjukkan ground-glass kekeruhan (GGO) dan konsolidasi (Ikuyama et al, 2020).…”

Section: Kasusunclassified

“…Gambar chest computed tomography (CT) menunjukkan ground-glass kekeruhan (GGO) dan konsolidasi. Pasien diberikan pengobatan Iopinavir-Ritonavir (400mg/100mg setiap 12 jam) oral, moxifloxacin 400 mg/ 24 jam oral, piperacillin dan tazobactam dan Piramivir (300mg/24 jam menjadi 150 mg/24 jam, globulin Imun Intravena (IVIG) 5000mg/24 jam dan methylprednisolone 250 mg/24 jam (Ikuyama et al, 2020).…”

Section: Kasusunclassified

Case Management for COVID-19 Pneumonia: Literature Review

Nurhayati

Pratiwi²

2020

Jurnal Berita Ilmu Keperawatan

View full text Add to dashboard Cite

Introduction: Coronavirus is a collection of viruses that can infect the respiratory system. In many cases, this virus only causes mild respiratory infections, such as flu. However, this virus can also cause severe respiratory infections, such as lung infections (pneumonia). The method is a literature review research in the form of case reports through the search of accredited journal sites such as Scientdirect and Elsevier with the keyword COVID-19 pneumonia in the period of 2015-2020. Research Results: in handling COVID-19 cases each country has its own way which consists of a physical examination, blood laboratory examination, chest CT scan, swab test, urine test, oxygen installation, mechanical ventilation, Extracorporeal Membrane Oxygention (ECMO) ), as well as the administration of drugs Ceftriaxone, Azithromycin, Piramivir, iopinavir-Ritonavir, Nafamostat and Intravenous Immune Globulin (IVIG), each patient differs based on history of illness. Conclusion: every region and every country has its own way of handling COVID-19 cases because until now there has been no definitive treatment or vaccine that can treat cases of COVID-19 that have struck all over the world.

show abstract

Mechanical circulatory support in coronavirus disease-2019-positive patients with severe respiratory failure

Natanov

Wiesner

Haverich

et al. 2021

Interactive CardioVascular and Thoracic Surgery

View full text Add to dashboard Cite

OBJECTIVES Treatment of severe acute respiratory distress syndrome (ARDS) induced by severe acute respiratory syndrome coronavirus 2 has been heavily debated. Our goal was to describe our findings in patients with severe ARDS due to severe coronavirus disease 2019 (sCOVID-19) treated with venovenous extracorporeal membrane oxygenation (vv-ECMO). METHODS We retrospectively examined all patients treated with vv-ECMO for severe ARDS due to acute respiratory syndrome coronavirus 2. RESULTS In total, 13 patients were treated with vv-ECMO in our medical centre. The mean patient age was 48.1 years. Most patients were obese (69%) and male (85%). All patients were mechanically ventilated before ECMO. The mean time from intubation to proning was 16.6 h; the time from start of prone therapy to vv-ECMO implantation was 155.1 h. The mean total ECMO run time was 358 h. Significant reduction of positive end-expiratory pressure (P = 0.02), peak pressure (P = 0.001) and minute volume (P = 0.03) could be achieved after implantation of vv-ECMO. All patients showed an inflammatory response. Overall mortality was 30.7%: 1 patient died of mesenteric ischaemia; 3 patients died of multiple organ failure. A worse prognosis was seen in patients with highly elevated concentrations of interleukin-6. CONCLUSIONS The use of vv-ECMO in patients with sCOVID-19-induced ARDS is safe and associated with improved respiratory ventilation settings. The rate of immune system involvement plays a pivotal role in the development and outcome of sCOVID-19.

show abstract

Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report

Cited by 7 publications

References 19 publications

Use of Venovenous Extracorporeal Membrane Oxygenation in Critically-Ill Patients With COVID-19

Use of Venovenous Extracorporeal Membrane Oxygenation in Critically-Ill Patients With COVID-19

Case Management for COVID-19 Pneumonia: Literature Review

Mechanical circulatory support in coronavirus disease-2019-positive patients with severe respiratory failure

Contact Info

Product

Resources

About