Successful rescue therapy with mycophenolate mofetil in kidney transplantation improves the long-term graft survival

Pulmonary arterial hypertension (PAH) is a severe clinical and pathophysiologic syndrome with no effective treatment at present. Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), has been applied widely to the treatment of connective tissue diseases with the effect of immunosuppressant. Its anti-proliferation has been found recently. Thereby, we tried to examine the effects of MMF on rats with PAH which was induced by monocrotaline injection, so as to investigate the mechanisms of treatment on PAH by MMF. The results substantiated that MMF therapy can alleviate thickening of pulmonary arterial walls and inhibit abnormal vascular remodeling, and the MPA concentrations which demonstrated efficacy in this study are within clinical applicable range, suggesting huge potentiality of MMF in the treatment of human PAH.

show abstract

The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats

Zheng

Zhang

et al. 2009

Rheumatol Int

View full text Add to dashboard Cite

show abstract

Anti-thymocyte globulins in kidney transplantation: focus on current indications and long-term immunological side effects

Bamoulid

Staeck

Crépin

et al. 2016

Nephrol. Dial. Transplant.

View full text Add to dashboard Cite

Antithymocyte globulins (ATGs) are part of the immunosuppression arsenal currently used by clinicians to prevent or treat acute rejection in solid organ transplantation. ATG is a mixture of non-specific anti-lymphocyte immunoglobulins targeting not only T cell subsets but also several other immune and non-immune cells, rendering its precise immunoglobulin composition difficult to appreciate or to compare from one preparation to another. Furthermore, several mechanisms of action have been described. Taken together, this probably explains the efficacy and the side effects associated with this drug. Recent data suggest a long-term negative impact on allograft and patient outcomes, pointing out the need to better characterize the potential toxicity and the benefit-risk balance associated to this immunosuppressive therapy within large clinical trials.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Successful rescue therapy with mycophenolate mofetil in kidney transplantation improves the long-term graft survival

Cited by 2 publications

References 12 publications

The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats

The effects and mechanisms of mycophenolate mofetil on pulmonary arterial hypertension in rats

Anti-thymocyte globulins in kidney transplantation: focus on current indications and long-term immunological side effects

Contact Info

Product

Resources

About