Successful salvage of a relapsed high risk gestational trophoblastic neoplasia patient using capecitabine

Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology

“…Successful use of capecitabine as single-agent salvage chemotherapy has been reported. 120,121 Groups in Asia have also reported on fluorouracil, primarily in combination with dactinomycin. 70…”

Refractory Choriocarcinoma: Complete Response With Oral Etoposide

“… 2 , 3 The agents that have shown response in refractory GTT include ifosfamide, 4 gemcitabine, 5 and capecitabine. 6 Ifosfamide alone or in combination (eg, combined etoposide, ifosfamide, and cisplatin) are active in patients with refractory disease. 4 Gemcitabine plus cisplatin has shown activity in a patient who progressed after combination chemotherapy and EP-EMA.…”

“… 5 Capecitabine alone can produce complete and long-lasting remission in refractory GTT. 6 If there is biochemical remission, then it could be consolidated with high-dose chemotherapy supported with peripheral blood stem cells. 7 …”

Treatment of Extremely High Risk and Resistant Gestational Trophoblastic Neoplasia Patients in King Chulalongkorn Memorial Hospital

“…In patients who resisted second line chemotherapy, third line chemotherapy may be considered. Several regimens were proposed as third line treatment such as TP/TE, BEP, ICE, Carboplatin/ Gemcitabine (Bianconi et al, 2007;Wong et al, 2008;Patel et al, 2010;Feng et al, 2011;Alazzam et al, 2012;Lurain et al, 2012). The efficacy of those regimens was acceptable (Bianconi et al, 2007;Feng et al, 2011;Lurain et al, 2012).…”