Successful spontaneous breathing trial, early reintubation and mechanisms of weaning failure

Sanfilippo, Filippo; Murabito, Paolo; Rosa, Valeria La; Oliveri, Francesco; Astuto, Marinella

doi:10.1007/s00134-020-06176-2

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…The patient must be weaned from mechanical ventilation as soon as possible 1 . Failure to wean is a challenge for intensive care physicians, twenty to thirty percent of weaning attempts are unsuccessful 2 .…”

Section: Introductionmentioning

confidence: 99%

The Association of Weaning Outcome with Left Ventricular Diastolic Dysfunction in Critically Ill Patients

Zafar,

Haidri,

Arain

et al. 2023

PJMHS

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Objectives: The aim of this study is to investigate the correlation between left ventricular diastolic dysfunction and successful weaning from mechanical ventilation in patients who are critically ill. Methods: An observational study was conducted at the ICU of the Sindh Institute of Urology and Transplantation (SIUT) in Karachi from April 2022 to December 2022. Essential baseline features including age, gender, duration of hospital stay, and ICU admission were documented using a predetermined proforma. Throughout the spontaneous breathing trial (SBT), hemodynamic evaluation was performed and recorded. Furthermore, respiratory and echocardiography parameters during the SBT trial as well as weaning results were documented. Results: The research involved 103 participants, with the majority being male. Among the 40 individuals who had diastolic dysfunction, there was a noteworthy occurrence of weaning failure in 29 patients (72.5%) which was found to have statistical significance (p=0.004). Additionally, a significant correlation between LV diastolic dysfunction and in-hospital mortality (p=0.003) was discovered. In addition, an extended duration of mechanical ventilation exceeding five days significantly corresponded with LV diastolic dysfunction (p=0.007). Conclusion: The results of our study provide additional proof to reinforce the importance of left ventricular diastolic dysfunction in predicting weaning failure from mechanical ventilation. This discovery can help medical professionals understand better how monitoring a patient's cardiac function during weaning is crucial, particularly with critically ill individuals. By recognizing the significance of LV diastolic dysfunction in this context, doctors and nurses can take proactive measures to monitor and treat any potential issues. Keywords: Weaning outcome, Left ventricular diastolic dysfunction, critically ill patients

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Section: Introductionmentioning

confidence: 99%

The Association of Weaning Outcome with Left Ventricular Diastolic Dysfunction in Critically Ill Patients

Zafar,

Haidri,

Arain

et al. 2023

PJMHS

View full text Add to dashboard Cite

show abstract

“…We read with interest the correspondence by Sanfilippo et al [ 1 ] who suggest performing further analysis for our recently reported study [ 2 ]. As per their thoughtful suggestion, we first redefined the two study groups as “weaning success” ( n = 43) when the patient could be extubated without reinstitution of ventilator support within 48 h after extubation, and as “weaning failure” ( n = 16) whenever one the following occurred: (i) failed spontaneous breathing trial (SBT) ( n = 12); (ii) reintubation and/or resumption of ventilator support within 48 h after extubation ( n = 3); or (iii) death in the 48 h after extubation ( n = 1) [ 3 ].…”

mentioning

confidence: 96%