Successful Surgical Decompression of Spinal Extradural Metastases of Liposarcoma

Bogoch, Earl R.; English, Emily; Perrin, Richard G.; Tator, Charles H.

doi:10.1097/00007632-198304000-00002

Cited by 11 publications

(4 citation statements)

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“…In this specific case, we should exclude metastases of liposarcoma. They occur in 22-45.8% of cases, often several years after treatment of the primary tumor [1,19]. The most frequent metastatic site is the lung [8,18] as was the case in our patient.…”

Section: Discussionsupporting

confidence: 55%

Primary liposarcoma of the thoracic spine: case report

et al. 2005

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Section: Discussionsupporting

confidence: 55%

Primary liposarcoma of the thoracic spine: case report

et al. 2005

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“…Our initial efforts in the management of patients with symptomatic spinal metastasis involved posterior decompression procedures. 7 ' 8 ' 4 -20 - 25 More recently we have accumulated a series of patients with symptomatic spinal metastasis treated by anterior decompression procedures. The purpose of this paper is to summarize our experience with anterior and posterior approaches, and to examine factors which determine the optimal surgical strategy for the treatment of patients with symptomatic spinal metastasis.…”

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confidence: 99%

Anterior Versus Posterior Decompression for Symptomatic Spinal Metastasis

Perrin

Mcbroom

1987

Can. J. Neurol. Sci.

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ABSTRACT:Management of patients with symptomatic spinal metastasis is designed to (1) relieve pain, and (2) restore or preserve neurologic function. The surgical strategy must include provisions for decompression of the dural sac and nerve roots, and stabilization of the spinal column. The optimal surgical approach, whether from in front or from behind is determined by a number of factors including (1) tumour location, (2) spinal level, (3) fixation factors, (4) patient debility.

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“…In multiple case reports and mixed histology studies, aggressive resection improves neurological and functional status and may extend survival. 2,4,5,9,25,27,34,35,38,43,58 However, in the vast majority of these older studies, palliative intralesional resections were performed. In contrast, treating extraspinal sarcomas with en bloc resections and wide or marginal negative margins has improved local tumor control and long-term survival.…”

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confidence: 99%

Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study

Dekutoski

Clarke²,

Rose

et al. 2016

SPI

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OBJECTIVE Primary spinal osteosarcomas are rare and aggressive neoplasms. Poor outcomes can occur, as obtaining marginal margins is technically demanding; further Enneking-appropriate en bloc resection can have significant morbidity. The goal of this study is to identify prognostic variables for local recurrence and mortality in surgically treated patients diagnosed with a primary osteosarcoma of the spine. METHODS A multicenter ambispective database of surgically treated patients with primary spine osteosarcomas was developed by AOSpine Knowledge Forum Tumor. Patient demographic, diagnosis, treatment, perioperative morbidity, local recurrence, and cross-sectional survival data were collected. Tumors were classified in 2 cohorts: Enneking appropriate (EA) and Enneking inappropriate (EI), as defined by pathology margin matching Enneking-recommended surgical margins. Prognostic variables were analyzed in reference to local recurrence and survival. RESULTS Between 1987 and 2012, 58 patients (32 female patients) underwent surgical treatment for primary spinal osteosarcoma. Patients were followed for a mean period of 3.5 ± 3.5 years (range 0.5 days to 14.3 years). The median survival for the entire cohort was 6.7 years postoperative. Twenty-four (41%) patients died, and 17 (30%) patients suffered a local recurrence, 10 (59%) of whom died. Twenty-nine (53%) patients underwent EA resection while 26 (47%) patients underwent EI resection with a postoperative median survival of 6.8 and 3.7 years, respectively (p = 0.048). EI patients had a higher rate of local recurrence than EA patients (p = 0.001). Patient age, previous surgery, biopsy type, tumor size, spine level, and chemotherapy timing did not significantly influence recurrence and survival. CONCLUSIONS Osteosarcoma of the spine presents a significant challenge, and most patients die in spite of aggressive surgery. There is a significant decrease in recurrence and an increase in survival with en bloc resection (EA) when compared with intralesional resection (EI). The effect of adjuvant and neoadjuvant chemotherapeutics, as well as method of biopsy, requires further exploration.

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Successful Surgical Decompression of Spinal Extradural Metastases of Liposarcoma

Cited by 11 publications

References 0 publications

Primary liposarcoma of the thoracic spine: case report

Primary liposarcoma of the thoracic spine: case report

Anterior Versus Posterior Decompression for Symptomatic Spinal Metastasis

Osteosarcoma of the spine: prognostic variables for local recurrence and overall survival, a multicenter ambispective study

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