Successful Surgical Management of Aortic Arch Thrombosis in the Neonate

Williams, Feifei; Clampitt-Holsenbeck, Amy; Lopilato, Alex Chase; Nazari, Reza; Zussman, Matthew; Reyes, Aurelio A. de los; Pigula, Frank A.

doi:10.1016/j.athoracsur.2020.05.091

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2021

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“…The surgical approach, either directly or using a transcatheter approach, has been performed in previous cases 7. Surgical intervention may be considered in those who fail to respond to medical therapy or those where medical therapy is contradicted due to high bleeding risk.…”

Section: Discussionmentioning

confidence: 99%

Bivalirudin and thrombolytic therapy: a novel successful treatment of severe aortic arch thrombosis in a term neonate

2021

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An early-term infant with uncomplicated perinatal history was found to have a large thrombus in the aortic arch after he failed regular newborn critical congenital heart defect screen. He responded well to bivalirudin thrombolytic and tissue-plasminogen activator (tPA) combination therapy, with a significant resolution of the thrombus. The infant tolerated hospital admission well with no significant complications. He was discharged home on daily aspirin at 2 weeks of life. To our knowledge, the combination therapy approach with bivalirudin and tPA is the first one reported in the literature in the neonatal age group.

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Section: Discussionmentioning

confidence: 99%