Successful Term Pregnancy Following Conservative Debulking Surgery for a Stage IIIA Serous Low-Malignant-Potential Tumor of the Ovary: A Case Report

Miller, Dianne; Ehlen, Thomas; Saleh, Edwyn

doi:10.1006/gyno.1997.4809

Cited by 22 publications

(5 citation statements)

References 6 publications

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“…Is it possible, however, to recommend conservative surgery to patients with peritoneal implants? There are few reports about this type of management, most of which are case reports 12–16 . In larger studies that focus on the assessment of fertility results in patients with all stage of disease, Gottlieb et al 4 reported three cases (two with Stage II and one Stage III disease) in patients with advanced stage, and Morris et al 5 three cases (with Stage III disease) 4,5 .…”

Section: Discussionmentioning

confidence: 99%

Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary

Camatte

Morice

Pautier

et al. 2002

BJOG

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Objective To assess the fertility of patients treated conservatively for a Stage II or III borderline ovarian tumour. Design A retrospective study. Setting Gynaecological oncology department in a French anti‐cancer centre. Population Seventeen patients treated with conservative management for a Stage II (n= 6) or III (n= 11) borderline ovarian tumour were followed up. Fifteen patients underwent a unilateral salpingo‐oophorectomy (with contralateral cystectomy in six patients), one had unilateral cystectomy and one a bilateral cystectomy. Fourteen patients had non‐invasive implants and three had invasive implants. Main outcome measures Pregnancy rates and outcome. Results Eight pregnancies were observed in seven patients in a median delay of eight months following the surgical procedure. Six pregnancies were observed spontaneously, one occurred after an ovarian stimulation and one after an IVF procedure. None of these patients recurred under the form of invasive ovarian carcinoma on the spared ovary. Two patients (one with a non‐invasive disease and one with an invasive one) had recurrence in the form of evolutive invasive implants, but neither woman died. Conclusion Spontaneous pregnancy can occur after conservative treatment of advanced stage borderline tumour of the ovary (with non‐invasive implants). Such management, performed in a close follow up of the patients, does not affect the overall survival. Conservative surgery could be proposed in patients with borderline tumour of the ovary and non‐invasive peritoneal implants.

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Section: Discussionmentioning

confidence: 99%

Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary

Camatte

Morice

Pautier

et al. 2002

BJOG

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“…Molecular markers in residual normal ovarian tissue do not change much in the case of ascites, which suggests that there is still a chance that normal ovarian tissues can be acquired for transplantation even in the case of widespread metastasis. Actually, it was reported that even patients with end-stage ovarian cancer have had successful operations in which the focal cancer was removed and the residual tissues functioned well without metastasis (Miller et al, 1997;Dykgraaf et al, 2009). As long as we regulate screening conditions, residual normal ovarian tissues can be transplanted securely.…”

Section: Discussionmentioning

confidence: 99%

Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice

Zhu¹,

Wang²,

Yao³

et al. 2014

Genet. Mol. Res.

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“…In clinical practice, it is common that normal ovarian tissues without invasion can be found in ipsilateral or contralateral ovary of patients with epithelial ovarian cancer. Actually, it is reported that some patients with advanced ovarian cancer accept large resection of foci and their residual tissues have normal function and metastasis does not appear after surgery (Miller et al, 1997;Dykgraaf et al, 2009). These residual normal ovarian tissues may contain residual cancer cells or have potential metastasis tendency.…”

Section: Discussionmentioning

confidence: 99%

Safety Assessment of Ovarian Cryopreservation and Transplantation in Nude Mice Bearing Human Epithelial Ovarian Cancer

Zhu¹,

Wang²,

Song³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Successful Term Pregnancy Following Conservative Debulking Surgery for a Stage IIIA Serous Low-Malignant-Potential Tumor of the Ovary: A Case Report

Cited by 22 publications

References 6 publications

Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary

Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary

Screening of the residual normal ovarian tissue adjacent to orthotopic epithelial ovarian carcinomas in nude mice

Safety Assessment of Ovarian Cryopreservation and Transplantation in Nude Mice Bearing Human Epithelial Ovarian Cancer

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