This study focussed on the therapeutic management of non-perforating abomasal ulcers in cattle. A total of 442 cattle having gastrointestinal disorders were screened based on the presence of melena and positive faecal occult blood tests (FOBT). Among these cases, only 15 were identified as non-perforating abomasal ulcers and further confirmation was done by serum pepsinogen. Out of this, 12 cases were selected for the study and cattle were divided into two groups, Group II received Inj. Ranitidine @ 3 mg/kg b.wt intramuscular BID for 5 days and Group III cattle received Inj. Pantoprazole @ 1 mg/kg b.wt intravenous, SID for 5 days. The treatment evaluation by clinical improvement, haematology, serum biochemistry, serum electrolytes, rumen chloride, serum pepsinogen, serum NEFA and blood gas changes were performed on day 0 of pre-treatment and day 5 post-treatment in both groups. Pantoprazole @ 1 mg/kg b.wt SID IV for 5 days showed early recovery as compared to ranitidine against non-perforating abomasal ulcer in cattle.