Successful therapy of a patient with therapy recalcitrant generalized bullous scleroderma by extracorporeal photopheresis and mycophenolate mofetil

Abstract

2 Farrar MD, Ingham E. Acne: inflammation. Clin Dermatol 2004; 22: 380-384. 3 Shalita AR, Myers JA, Krochmal L, Yaroshinsky A. The safety and efficacy of clindamycin phosphate foam 1% versus clindamycin phosphate topical gel 1% for the treatment of acne vulgaris. J Drugs Dermatol 2005; 4: 48-56. 4 Lawson EE, Edwards HG, Barry BW, Williams AC. Interaction of salicylic acid with verrucae assessed by FT-Raman spectroscopy. J Drug Target 1998; 5: 343-351. 5 Shalita AR. Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris. Clin Ther 1989; 11: 264 -267. 6 Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes -novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Contr Rel 2000; 65: 403-418. 7 Touitou E, Godin B. Enhanced skin permeation using ethosomes. In: Smith E, Maibach HI, eds. Percutaneous Penetration Enhancers, 2nd edn. CRC Press, New York, 2005: 95-108. 8 Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M.Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.

European Dermatology Forum S1‐guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes

“…UVA1 is usually performed 3–5 times weekly for a minimum of 30 irradiations. Success with extracorporeal photopheresis has also been described in case reports …”

“…Success with extracorporeal photopheresis has also been described in case reports. [86][87][88][89] Physiotherapy Studies on physiotherapy in LS are lacking. Nevertheless, physiotherapy is an important component in the multimodal treatment concept for LS, especially for linear, generalized, deep and mixed types of LS.…”

Mycophenolic Acid (Cellcept and Myofortic) Induced Injury of the Upper GI Tract

“…MPA is commonly used in kidney transplanted patients on the basis of the improvement in toxicity over previous cyclosporine based regimens, 1,11 but it has been used to treat a host of diverse immune conditions 6,7,9,12,16,20,[24][25][26][29][30][31] in addition to its established role in maintenance of solid organ transplants. 3 As GI side effects are common, we would expect to encounter GI biopsies from patients with MPA-associated injury with increasing frequency in daily practice.…”

A systematic review of morphea treatments and therapeutic algorithm

“…One case of bullous generalized morphea did not respond to mycophenolate mofetil after 1 year of use. 45 Summary. Intralesional interferon gamma is not an effective treatment for morphea according to level-1 evidence.…”