Successful thrombolysis of a symptomatic neonatal aortic thrombosis associated with hypernatraemic dehydration - case report and literature review

Neonatal aortic arch thrombosis: analysis of thrombophilic risk factors and prognosis

“…According to this case series and other reports, the thrombotic occlusion of the descending aorta seems to be much more common than the thrombotic occlusion of the aortic arch. 9,[19][20][21][22][23][24] The two reported patients from our centre were carriers of a heterozygous factor V Leiden mutation. One had an additional thrombophilic risk factor: he was positively tested for antiphospholipid antibodies.…”

Multimodality and multiterritory vascular imaging in a toddler with acquired, complex, and unusual aortic arch anatomy

“…2,3 Most neonates require surgical intervention in the form of thrombectomy and some sort of arch repair; thrombolysis is used occasionally. [2][3][4][5][6] Overall, mortality rate of aortic arch thrombosis is about 25-fold higher (52%) compared with the reported 2% mortality rate of typical coarctation. 7,8 Thromboembolism of both venous and arterial sides is more common in infants and neonates than in children.…”

“…Spontaneous aortic thrombosis appears to occur almost always in male neonates within hours after birth, presenting with hemodynamic compromise, cyanosis, or differential peripheral pulses . Most neonates require surgical intervention in the form of thrombectomy and some sort of arch repair; thrombolysis is used occasionally . Overall, mortality rate of aortic arch thrombosis is about 25‐fold higher (52%) compared with the reported 2% mortality rate of typical coarctation …”

Dehydration as a Rare Cause of Pulmonary Artery Thrombosis in a 2-Week-Old Term Neonate

“…8,9 There are only a few reports of neonates with arterial thrombosis due to dehydration but none with pulmonary arterial thrombosis. 10,11 Here, we describe a neonate who was severely dehydrated and developed significant respiratory and cardiovascular compromise following pulmonary artery thrombosis and presented to the pediatric intensive care unit (PICU) in critical condition. She survived to discharge thanks to a definitive diagnosis and aggressive management.…”