Successful trans-maternal nadolol pharmacotherapy in a fetus presenting with long QT syndrome type 2 complicated by torsade de pointes

Shima, Y.; Horigome, Hitoshi; Nozaki, Yoshihiro; Lin, Lisheng; Ishiodori, Takumi; Yano, Yusuke; Takahashi, Miho; Murakami, Takashi; Yamasaki, Hiro; Takada, Hidetoshi

doi:10.1016/j.jccase.2020.07.006

Cited by 2 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It may be diagnosed prenatally with a family history, a characteristic arrhythmia, bradycardia, and associated findings such as AV block or torsades de pointes (TdP). One case of iLQTS was reported to be treated with trans-maternal nadolol, which was shown to be effective in the restoration of fetal sinus rhythm [ 80 ]. A review examining beta-blocker usage in pregnant women with iLQTS observed the subsequent effects on the uterus, fetal birth weight, and fetal glycemic levels.…”

Section: Reviewmentioning

confidence: 99%

Beta-Blockers and Their Current Role in Maternal and Neonatal Health: A Narrative Review of the Literature

Martinez,

Lakkimsetti,

Maharjan

et al. 2023

Cureus

View full text Add to dashboard Cite

Beta-blockers are a class of medications that act on beta-adrenergic receptors and are categorized as cardio-selective and non-selective. They are principally used to treat cardiovascular conditions such as hypertension and arrhythmias. Beta-blockers have also been used to treat non-cardiogenic indications in non-pregnant individuals and the pediatric population. In pregnancy, labetalol is the mainstay treatment for hypertension and other cardiovascular indications. However, contraindications to certain sub-types of beta-blockers include bradycardia, heart failure, obstructive lung diseases, and hemodynamic instability. There is conflicting evidence of the adverse effects on fetal and neonatal health due to a scarce safety and efficacy profile, and further studies are necessary to understand the pharmacokinetics of the different classes of beta-blockers in pregnancy and fetal health. Understanding the hemodynamic changes during the stages of pregnancy is important to target a more beneficial therapy for both mother and fetus as well as better neonatal outcomes. Beta-blocker use in the pediatric population is less documented in studies but does have the potential to treat various cardiogenic and non-cardiogenic conditions. Future comprehensive studies would further benefit the direction of beta-blocker treatment during pregnancy in neonates and pediatrics.

show abstract

Section: Reviewmentioning

confidence: 99%

Beta-Blockers and Their Current Role in Maternal and Neonatal Health: A Narrative Review of the Literature

Martinez,

Lakkimsetti,

Maharjan

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

Fetal Long QT Syndrome – Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy

Wegner,

Steinhard,

Frank

et al. 2024

Z Geburtshilfe Neonatol

View full text Add to dashboard Cite

Congenital LQTS is an often undetected inherited cardiac channel dysfunction and can be a reason for intrauterine fetal demise. It can present in utero as CTG and ultrasound abnormalities, i. e., bradycardia, ventricular tachycardia, or fetal hydrops. Diagnosis is made by CTG, echocardiography, or fMCG. Intrauterine therapy with a ß blocker and i. v. magnesium should be started. Our objective was to examine the current knowledge about diagnosis and treatment of LQTS and in particular to highlight the opportunity of vaginal birth under continuous intravenous magnesium therapy. Therefore, a thorough MEDLINE and Google Scholar search was conducted. Randomized controlled trials, meta-analyses, prospective and retrospective cohort trials, and case reports were considered. We showed the possibility of vaginal delivery under continuous magnesium therapy in a case of suspected fetal LQTS. A stepwise concept for diagnosis, monitoring, and peripartum management in low, intermediate, and high risk cases of fetal LQTS is presented. If risk is low or intermediate, a vaginal delivery under continuous monitoring is reasonable. Induction of labor at term should be evaluated.

show abstract

Successful trans-maternal nadolol pharmacotherapy in a fetus presenting with long QT syndrome type 2 complicated by torsade de pointes

Cited by 2 publications

References 9 publications

Beta-Blockers and Their Current Role in Maternal and Neonatal Health: A Narrative Review of the Literature

Beta-Blockers and Their Current Role in Maternal and Neonatal Health: A Narrative Review of the Literature

Fetal Long QT Syndrome – Challenges in Perinatal Management: A Review and Case Report. Induction of Labor and Vaginal Birth Under Continuous Magnesium Therapy

Contact Info

Product

Resources

About