The term HTLA, standing for high-titer, low-avidity, has been used to name a category into which a group of IgG antibodies has been placed arbitrarily. Most examples of the antibodies in this group share several serological characteristics. First, the antibodies react weakly in the antiglobulin phase of hemagglutination tests. Second, they may not react to the same extent with the red cells of different antigen-positive donors: reaction strengths may vary from weakly macroscopic to microscopic. Third, the antibodies continue to produce the same weak reactions at high dilutions (1:64 or higher).While these serological characteristics have been considered to be a hallmark of the antibodies in this group, it must be mentioned that some samples will be encountered that neither react to high dilutions nor produce weak or variable antiglobulin reactions. The variations in reactions seen with some HTLA antibodies and different red cell samples suggest that antigen density varies from the red cells of one donor to another. Some donor's red cells may carry so little antigen and react so poorly in antiglobulin tests that they may be difficult to distinguish from antigen-negative red cells.Antibodies grouped under the HTLA heading include anti-Csa (Cost-Stirling), -Csb (Ste), -Yka (York), -Kna (Knops-Helgeson), -Knb (Hall), the McCoy group -McCa through -McCf, -SIa (Swain-Langley), -Slb, -JMH (John Milton Hagen), -Ch (Chido) and -Rg (Rodgers). 1-20 Some workers have also placed antibodies such as anti-Hy,21.22 lncidences AntigenWhites (%) Blacks (%)