Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Zhang, Hai; Liu, Ming‐Hua; Zhang, Jie; Shu-peng, Luo; Wang, Chao‐Bo; Zhao, Z X; Ge, Yanli; Zhang, Jian‐Yu; Geng, Fenghao

doi:10.1002/ccr3.2568

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…A pesar de que aún no exista un tratamiento estándar y los resultados no son del todo favorables, el tratamiento principal se basa en quimioterapia, con diferentes tipos de esquemas, desde un solo agente hasta varios agentes, incluso utilizando radioterapia 2,8 .…”

Section: Residente Deunclassified

Caso de desafío diagnóstico

2021

Rev. chil. radiol.

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Section: Residente Deunclassified

Caso de desafío diagnóstico

2021

Rev. chil. radiol.

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“…6,9 Conventional chemo-and radiotherapies have proven unsuccessful in most cases and only isolated survivors have been documented. 10,11,12,13 Consequently, numerous targeted therapies are under investigation in the hope of finding a cure. 14,15,16,17,18 As this is a translocation-associated tumour with a simple karyotype, these targeted therapies are aimed towards epigenetic components, including histone deacetylase inhibitors, bromodomain and extra-terminal motif (BET) inhibitors or specific components of the cell cycle.…”

Section: Introductionmentioning

confidence: 99%

Nuclear protein in testis (NUT) carcinoma in the public sector of the Free State province, South Africa

Roets

Pretorius

Joubert

et al. 2020

South African Journal of Oncology

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Methods: In this retrospective study, all undifferentiated malignant tumours and tumours with evidence of squamous differentiation from the head, neck and thorax seen between 01 January 2005 and 31 December 2016 were included. Nuclear protein in testis immunohistochemical staining was performed on all specimens. The stain was regarded as positive if speckled nuclear staining was observed in more than 50% of the tumour cells.Results: In total, 498 cases were investigated, of which 424 (85.1%) belonged to male patients. The mean age of the patients was 58.6 years. Only one positive case, a 30-year-old woman with a lung mass and lymph node metastases, was identified. Conclusion:Our findings confirmed the rarity of NC. Additional research in other provinces and the private sector is recommended to provide a comprehensive patient profile of NC in South Africa.

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NUT carcinoma of the head and neck: A case report and literature review

Zhao,

Zhang,

Liao

et al. 2024

Precision Radiation Oncology

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Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive cancer, characterized by rearrangements involving the NUT gene located on chromosome 15q14. In this report, we present the case of a 52‐year‐old female diagnosed with primary parotid NUT carcinoma. Despite undergoing surgery, adjuvant chemotherapy, and incomplete regional radiotherapy, the patient succumbed to the disease after an overall survival duration of 7 months. We retrospectively discuss patient clinical and pathological features, as well as therapeutic approaches of NUT carcinoma of the head and neck.

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Successful treatment of a case with NUT midline carcinoma in the larynx and review of the literature

Cited by 6 publications

References 15 publications

Caso de desafío diagnóstico

Caso de desafío diagnóstico

Nuclear protein in testis (NUT) carcinoma in the public sector of the Free State province, South Africa

NUT carcinoma of the head and neck: A case report and literature review

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