Successful treatment of accessory breast cancer with endocrine therapy

Abstract

Accessory breast cancers in males are extremely rare, and only a few cases have been reported in the literature. In this paper, an 87-year-old male patient was diagnosed with an accessory breast cancer by means of computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), and immunohistochemistry based on needle biopsy, and has undergone successful resection and postoperative adjuvant endocrine therapy. He was the oldest male patient with an accessory breast cancer reported in the Chinese Hospital Knowledge Database and PubMed literature from 1975 to 2015.

Diagnosis and Treatment of Male Accessory Breast Cancer: A Comprehensive Systematic Review

“…The tumor had the following immunohistochemical characteristics: Ki-67(-), ER(+), PR(+), and HER2(-). In addition, Wand et al (16) reported a case of accessory male breast cancer in which an 87-year-old male patient was treated with hormone therapy. Considering the chemotherapy-related toxicity, adjuvant chemotherapy was not considered suitable for this patient (tamoxifen at 20 mg/day).…”

Ectopic Male Breast Cancer in Suprapubic Area That Relapsed with Hematogenous Metastasis

“…In the English literature, only 10 cases of ectopic male breast cancer have been reported till date [ 2 3 4 5 6 7 8 9 10 11 ]. The most common site of ectopic male breast cancer is the axilla [ 3 4 6 7 8 9 10 11 ]. Until now, only 2 cases of non-axillary ectopic male breast cancer (in the lower abdominal wall and perineum) have been reported [ 2 5 ].…”

“…To date, only conventional prognostic factors such as anatomic-based tumor-node-metastasis (TNM) staging, molecular subtype, histologic grade, and Ki-67 are used to predict the prognosis of ectopic male breast cancer as with female breast cancer. Among reported ectopic male breast cancers [ 2 3 4 5 6 7 8 9 10 11 ], 30% (3/10) cases were already at the T4 stage or had bone metastasis when the diagnosis was established [ 3 10 11 ]. One patient had pathologic stage pT1N1M0 cancer and had relapsed with multiple distant metastases [ 6 ].…”

“…The prognosis of ectopic male breast cancer is unknown owing to its rarity. Therefore, there is no clear consensus on the prognosis and follow-up of male patients with ectopic breast cancer after complete surgical resection [ 3 4 ]. We report the case of a 65-year-old male patient with ectopic breast cancer in the suprapubic area that relapsed with hematogenous metastasis despite an early diagnosis.…”

Axillary Reverse Lymphatic Mapping in the Treatment of Axillary Accessory Breast Cancer: A Case Report and Review of Management

“…According to Maki et al, ALND is the most common surgical approach and is performed in 64% of cases 14 . Most surgeons advocate for routine ALND as part of the primary surgery due to the higher rate of nodal involvement and the potential for obscuration of sentinel nodes after tracer injection, given their proximity to the tumor [14][15][16][17] . However, there are reported cases of negative lymph nodes after ALND 16,18 , which raises the concern of overtreatment in these patients.…”