Successful treatment of acute respiratory distress syndrome caused by hypervirulent Klebsiella pneumoniae with extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review

Peng, Wenzhong; Wu, Yanhao; Lu, Ruifeng; Zheng, Yunpeng; Chen, Jie; Pan, Pinhua

doi:10.3389/fmed.2022.936927

Cited by 3 publications

(3 citation statements)

References 65 publications

(45 reference statements)

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“…Carbapenemresistant Klebsiella pneumoniae, ESBL-positive, detected during bronchoscopy, is among the concerning pathogens. The risk of mortality for individuals infected with it escalates with age [11]. In our patient, based on the antibiogram, targeted meropenem was used for treatment.…”

Section: Discussionmentioning

confidence: 96%

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Pneumothorax as a complication of respiratory failure – two case reports and literature review

Krawczyk,

Chajec,

Paluch

et al. 2024

J Pre Clin Clin Res.

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Acute respiratory distress syndrome (ARDS) -severe clinical syndrome with a high mortality rate, is characterized by hypoxemia and respiratory failure secondary to non-cardiogenic pulmonary oedema. The most common cause of ARDS is pneumonia. The cases are presented of 2 male patients: a 28-year-old and a 41-year-old, who were in a severe general condition due to progressive respiratory failure secondary to pneumonia. Despite antibiotic therapy the condition of the patients deteriorated. A differential diagnosis was performed, in which autoimmune causes, tuberculosis and viral infections were excluded. During hospitalization, both men developed pneumothorax requiring urgent drainage. A decline and deterioration of the patients' vital signs was observed and eventually death was pronounced. ARDS is a severe disease that poses a challenge in clinical practice. The course of the disease is difficult to predict, and the patient requires intensive surveillance and treatment.

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Section: Discussionmentioning

confidence: 96%

“…In patients with ARDS, accompanied by septic shock, the use of the VV ECMO procedure is not always possible, and sometimes there may be a need to consider switching to venoarterial extracorporeal membrane oxygenation (VA ECMO). Data on patients with COVID-19 show high mortality associated with extracorporeal membrane oxygenation [11].…”

Section: Discussionmentioning

confidence: 99%

Pneumothorax as a complication of respiratory failure – two case reports and literature review

Krawczyk,

Chajec,

Paluch

et al. 2024

J Pre Clin Clin Res.

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“…[22][23][24] There is currently a report of successful treatment of hypervirulent KP (hvKP) infection in ECMO patients. 25 However, there is not much experience in treatment of MDR-GNB in ECMO patients.…”

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confidence: 99%

The Etiological and Drug Resistance Characteristics of Multidrug-Resistant Pathogens in Patients Requiring Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study

Gao¹,

Wang²

2023

IDR

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Infections induced by multidrug-resistant (MDR) pathogens are one of the most common and serious complications in extracorporeal membrane oxygenation (ECMO) patients. However, there is currently little research about "ECMO and MDR bacteria". The purpose of our study was to clarify the epidemiological characteristics of MDR bacteria and provide references for empiric antibiotic treatments according to the drug susceptibility tests for ECMO patients. Patients and Methods: There were 104 patients admitted to our department and receiving ECMO treatments between January 2014 and December 2022. Altogether, 61 veno-arterial ECMO (VA-ECMO) and 29 veno-venous ECMO (VV-ECMO) patients enrolled. The data on other intensive care unit (ICU) patients in our department in the same period are summarized. Results: A total of 82 MDR bacteria were detected from ECMO patients, and most of these were MDR Gram-negative bacteria (MDR-GNB). There were also 5559 MDR-GNB collected from other patients in our department in the same period. We found that the distribution of MDR-GNB in ECMO patients was different from other critical patients. The proportion of Klebsiella pneumoniae (MDR-KP) in VV-ECMO patients was higher than other critical patients (35.1% and 21.3%, respectively). Moreover, the proportions of MDR Acinetobacter baumannii (MDR-AB) of VA-ECMO and VV-ECMO were higher than other critical patients (54.6%, 43.2% and 30.5%, respectively). In addition, MDR-AB and MDR-KP in ECMO patients exhibited higher percentages of drug resistance to possibly appropriate antibiotics for other critical patients, but showed better sensitivity to colistin. Conclusion: Infections induced by MDR-GNB in ECMO patients were serious and exhibited higher degrees of drug resistance compared with other ICU patients. Colistin might be an option to consider if there is no medical contraindication. However, widespread use of broad spectrum antibiotics is something that should be discouraged, and alternative options are being explored.

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Inhibiting lipid droplet biogenesis enhances host protection against hypervirulent Klebsiella pneumoniae infections

Jung,

Kim,

Hyun

et al. 2024

Med Microbiol Immunol

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Successful treatment of acute respiratory distress syndrome caused by hypervirulent Klebsiella pneumoniae with extracorporeal membrane oxygenation and continuous renal replacement therapy: A case report and literature review

Cited by 3 publications

References 65 publications

Pneumothorax as a complication of respiratory failure – two case reports and literature review

Pneumothorax as a complication of respiratory failure – two case reports and literature review

The Etiological and Drug Resistance Characteristics of Multidrug-Resistant Pathogens in Patients Requiring Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study

Inhibiting lipid droplet biogenesis enhances host protection against hypervirulent Klebsiella pneumoniae infections

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