Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature

Rudaitis, Vilius; Mickys, Ugnius; Katinaitė, Justina; Dulko, Justyna

doi:10.6001/actamedica.v23i2.3327

Cited by 11 publications

(17 citation statements)

References 31 publications

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“…On MRI, yolk sac tumors can show areas of signal voids related to rich vascularization [ 15 ] or areas of hemorrhage. Cross-sectional imaging is valuable in the assessment of the full extent of metastatic spread into the lymph nodes, omentum, lungs, liver, and bones [ 16 ]. In advanced stages, surgical treatment aims to provide complete cytoreduction without systematic lymph node dissection; however, the procedure may be modified to minimize surgical morbidity in view of high chemosensitivity to ensure no delays in postoperative chemotherapy [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Yolk Sac Tumor of the Omentum: A Case Report and Literature Review

et al. 2022

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This is a case report of a rare finding of an extragonadal yolk sac tumor in a 37-year-old patient who presented with shortness of breath and abdominal bloating. During imaging and staging surgery, the findings were strongly suggestive of an extragonadal advanced tumor presenting with peritoneal dissemination, predominantly affecting omentum, with no clear primary origin. Histology revealed an extragonadal yolk sac tumor in a pure form outside the ovaries. Lacking an obvious origin elsewhere, the tumor was highly suspected to have truly originated from the omentum. The patient underwent surgery and four cycles of chemotherapy consisting of cisplatin, etoposide, and bleomycin. One-year outpatient follow-up thereafter showed no relapse. We herein discuss a possible site of the tumor origin and its development, as well as diagnostic challenges and disease prognosis.

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Section: Discussionmentioning

confidence: 99%

Yolk Sac Tumor of the Omentum: A Case Report and Literature Review

et al. 2022

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“…In a case reported by Rudaitis et al 27 , NACT with four PEB cycles was chosen as an option to reduce tumor size and minimize the extent of the surgical procedure. In our case, the preoperative histology of the YST was acquired by biopsy.…”

Section: Discussionmentioning

confidence: 99%

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

Yin

Wang

Yang

2022

Journal of Pediatric and Adolescent Gynecology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Furthermore, it was reported that platinum-based chemotherapy should be used for the more malignant tumors such as endodermal sinus tumor and mixed germ cell tumor (45, 46). Neoadjuvant chemotherapy could be considered for the patients having extensive intra-abdominal disorders when initial surgical debulking is not preferred (47). Chemotherapy is suggested for treating recurrence (37).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, minimally invasive surgery has been proved to have better prognosis (34). Rudaitis et al (47) applied neoadjuvant chemotherapy of four BEP cycles to decrease the tumor size in order to minimize the extent of surgery and thus the impact on the patient's fertility. In spite of the risks of damaging the reproductive function of female patients involved in chemotherapy, previous investigations have revealed that most of the women could recover their normal menstrual and reproductive functions post treatment (49, 50).…”

Section: Discussionmentioning

confidence: 99%

Yolk Sac Tumor in an Eight-Year-Old Girl: A Case Report and Literature Review

Chen

Yip

et al. 2019

Front. Pediatr.

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Yolk sac tumor (YST), which most frequently arises in the gonads as a type of germ cell tumor, is rare in children but is highly malignant. It has been suggested that alpha-fetoprotein (AFP) can be applied as a feasible tumor marker because its level was elevated in >90% of YST. The treatment generally involves debulking surgery of tumors followed by systemic chemotherapy. Metastasis process of YST in children is different from that in adults and thus the treatment option is required. In this study, we described a rare case of YST in terms of the clinical manifestation, imaging, and histopathology findings, diagnosis and treatment in an 8-year-old girl. Furthermore, it is important to investigate more thoroughly a patient with history of intermittent abdominal pain and fever with previously multiple accesses, because these might be the critical signs for YST that should be alarmed for early treatment. Although YST is rare in children, pediatric physicians should be aware of this and prompt treatment should be addressed.

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Successful treatment of advanced stage yolk sac tumour of extragonadal origin: a case report and review of literature

Cited by 11 publications

References 31 publications

Yolk Sac Tumor of the Omentum: A Case Report and Literature Review

Yolk Sac Tumor of the Omentum: A Case Report and Literature Review

Yolk sac tumor of the uterus in a 2-year-old girl: A case report and literature review

Yolk Sac Tumor in an Eight-Year-Old Girl: A Case Report and Literature Review

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