SUCCESSFUL TREATMENT OF AN ENDODERMAL SINUS TUMOR OF THE VAGINA BY CHEMOTHERAPY ALONE: A Rare Case of an Infant Diagnosed by Pathological Examination of Discharged Tumor Fragment

Tanaka, Satoru; Ijichi, Osamu; Yoshikawa, Hiroyuki; Nonaka, Yukiko; Tanabe, Takayuki; Nishikawa, Takuro; Ishikawa, Syuji; Okamoto, Yasuhiro; Kaji, Tatsuru; Tahara, Hiroyuki; Takamatsu, Hideo; Nagata, Kohji; Kawano, Yoshifumi

doi:10.1080/08880010600856972

Cited by 12 publications

(4 citation statements)

References 17 publications

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“…Long-term irradiation has secondary effects of sterility, aseptic necrosis of the femoral head, and abnormal growth of the pelvic bones 7 . Treatment consists of conservative surgery in combination with chemotherapy, with excellent prospects for long-term survival 10 . One patient reported here underwent partial vaginectomy and received four cycles of combination chemotherapy with PEB.…”

Section: Discussionmentioning

confidence: 99%

Endodermal Sinus Tumor of Vagina in Infants

Chauhan¹,

Nigam

Singh

et al. 2013

Rare Tumors

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Endodermal sinus tumor (or Yolk Sac tumor) of the vagina is a rare malignant germcell tumor which is seen exclusively in children younger than 3 years of age. We report two cases of endodermal sinus tumor of the vagina. In both cases no radiological investigation was done and serum alpha-fetoprotein was elevated. The histopathological examination of both the tumor masses revealed vaginal endodermal sinus tumor. Periodic-acid-Schiff stain with diastase showed diastase resistant hyaline globules. These findings confirmed the diagnosis of endodermal sinus tumor in both cases. Vaginal endodermal sinus tumor is both locally aggressive and capable of metastasis. The serum alpha-fetoprotein level is a useful marker for diagnosis and monitoring the recurrence of vaginal endodermal sinus tumor in infants. Early detection and therapy is important because of its aggressive nature and good response to chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Endodermal Sinus Tumor of Vagina in Infants

Chauhan¹,

Nigam

Singh

et al. 2013

Rare Tumors

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“…Vaginal yolk sac tumor have been treated by some oncologist by exclusive chemotherapy which has also happened this case. 6,7…”

Section: Ct Scan Of Pelvic Organs (Axial View)mentioning

confidence: 99%

Vaginal yolk sac tumour in infant : A rare case report

Morshed,

Khan,

Khatun

et al. 2018

J. paediatr. surg. Bangladesh

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Malignant germ cell tumors are rare tumors in children accounting for 2-3% of childhood malignancies, usually occurring in midline structures. Yolk sac tumor is one of the form of Germ cell tumor among them extra gonadal yolk sac tumor is rare entity. Vaginal yolk sac tumor usually occurs below 3 years. Its occurrence in vagina is very rare & typically presents with vaginal bleeding, vaginal mass or sometimes mechanical urinary retention. We report a 10 months old girl presented with vaginal bleeding and high Alpha fetoprotein and as diagnosed as yolk sac tumor. Journal of Paediatric Surgeons of Bangladesh (2017) Vol. 8 (1): 36-37

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“…As they had been documented mostly as isolated reports or small series of 1 to 2 cases, outcomes and treatment strategy in this population remain unclear. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Biological disease heterogeneity, implied from the observation that not all patients respond to consistent treatment strategies, is poorly understood. Multimodal therapy was used with varying results.…”

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confidence: 99%

“…Cures have been reported even with the use of chemotherapy alone. 4,6,7,10,12,16,19 However, there is no clarity on optimal treatment strategy. We had the unique opportunity of managing and following up 6 girls with vYST over a 25-year period.…”

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confidence: 99%

Pediatric Vaginal Yolk Sac Tumor

Rajagopal

Ariffin

Krishnan

et al. 2015

Journal of Pediatric Hematology/Oncology

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Review of the management of 6 young girls with vaginal yolk sac tumor over 25 years showed that the α-fetoprotein levels normalized in 5/6 within 4 cycles of primary cisplatin, bleomycin, etoposide (PEB)/carboplatin, etoposide, bleomycin (JEB)/cisplatin, vinblastine, bleomycin (PVB) chemotherapy. Radioimaging revealed residual tissue but viable tumor was found in only 1 of 2 biopsied. Resection/biopsy is necessary to avoid giving additional primary chemotherapy or to identify patients who need different treatment. If markers do not decay appropriately, PEB/JEB/PVB chemotherapy should not be continued. Taxol-containing salvage chemotherapy regimens, adjuvant modern radiotherapeutic treatment, and fertility-saving curative surgery should then be considered. Despite having mostly advanced disease, 5/6 patients were cured, 2 with chemotherapy alone.

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SUCCESSFUL TREATMENT OF AN ENDODERMAL SINUS TUMOR OF THE VAGINA BY CHEMOTHERAPY ALONE: A Rare Case of an Infant Diagnosed by Pathological Examination of Discharged Tumor Fragment

Cited by 12 publications

References 17 publications

Endodermal Sinus Tumor of Vagina in Infants

Endodermal Sinus Tumor of Vagina in Infants

Vaginal yolk sac tumour in infant : A rare case report

Pediatric Vaginal Yolk Sac Tumor

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