Successful treatment of antisynthetase syndrome presenting as rhabdomyolysis with rituximab

Abstract

Rhabdomyolysis is a syndrome of muscle necrosis with subsequent release of intracellular content into the blood. There are various causes for rhabdomyolysis that include trauma, medications and rarely autoimmune conditions such as autoimmune myositis. Antisynthetase syndrome is an autoimmune condition characterized by positive antisynthetase antibody, myopathy, lung disease and arthritis. To our knowledge, rhabdomyolysis in antisynthetase syndrome has not been reported in the literature. In this report, we present a patient who presented with features of rhabdomyolysis and was diagnosed with antisynthetase syndrome. This patient was treated with systemic steroids with partial improvement, followed by rituximab, which led to significant improvement in his condition. In addition, we summarize all cases reported in the literature of inflammatory myopathy-associated rhabdomyolysis.

Rituximab in the treatment of progressive interstitial lung disease associated with the antisynthetase syndrome

“…Regarding the published case reports and case series, we identified 20 reports that describe a total of 65 patients with ASS-ILD [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Stabilization or significant improvement in ILD was reported in most cases, while there was only one mortality linked to Pneumocystis jirovecii pneumonia [38].…”

Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature

“…It was previously considered that rhabdomyolysis leading to acute renal failure was uncommon in PM and DM because the rate and degree of myolysis could be lower than those of myotoxic drug-related necrotizing myopathy [11]. However, myoglobinuria-induced acute tubular necrosis caused by PM or DM has been reported in the literature, especially in patients with DM [12][13][14][15][16][17][18][19][20]. e other type of renal damage related to PM or DM is chronic glomerulonephritis, which is presumed to be immune-mediated, and exhibits a variety of histologic features.…”