Successful Treatment of Calciphylaxis with Intravenous Sodium Thiosulfate in a Nonuremic Patient: Case Report and Review of Therapy Side Effects

Fernandes, Carolina; Maynard, Bruno; Hanna, Dominique

doi:10.2310/7750.2013.13117

Cited by 15 publications

(13 citation statements)

References 10 publications

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“…Although a theoretical benefit of vitamin K supplementation has been posed, data on benefits are limited, and safety of vitamin K supplementation remains unclear . The use of intravenous sodium thiosulfate appears to be beneficial but has been reported only in small nonrandomized studies …”

Section: Management Of Calciphylaxismentioning

confidence: 99%

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Pathogenesis and management of vascular calcification in CKD and dialysis patients

Kakani

Elyamny

Ayach

et al. 2019

Seminars in Dialysis

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Patients with chronic kidney disease (CKD) have a predisposition to develop vascular calcification due to dysregulated homeostatic mechanisms, which lead to an imbalance in the circulatory promoters and inhibitors of vascular calcification, leading to a net calcification stress. These factors promote ectopic calcification and induce vascular smooth muscle cells to undergo osteogenic differentiation and actively calcify the vascular media. The article summarizes clinically relevant pathogenic mechanisms of vascular calcification in patients with CKD and in dialysis patients and summarizes novel therapeutic interventions. In addition to the management of traditional cardiovascular risk factors, patients with CKD‐mineral and bone disorder need close attention in the management of the mineral metabolism to prevent adverse effects on the bone and vascular compartments. This article reviews current evidence and therapeutic guidelines in the management of mineral metabolism in CKD and dialysis.

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Section: Management Of Calciphylaxismentioning

confidence: 99%

“…92 The use of intravenous sodium thiosulfate appears to be beneficial but has been reported only in small nonrandomized studies. 93…”

Section: Manag Ement Of C Alciphyl a Xismentioning

confidence: 99%

Pathogenesis and management of vascular calcification in CKD and dialysis patients

Kakani

Elyamny

Ayach

et al. 2019

Seminars in Dialysis

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“…Initial pain was always rated highly, with VAS scores between 8–9/10 and 10/10. Severity of pain was directly associated with decreased QoL . Cases reported improvement with opioids and intravenous STS therapy, including one case of resolution to a VAS score of 0 .…”

Section: Resultsmentioning

confidence: 99%

Underreported use of palliative care and patient-reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review

Riemer¹,

el‐Azhary

et al. 2017

Br J Dermatol

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Calciphylaxis is associated with significant morbidity and mortality. Palliative care (PC) is a subspecialty that treats the pain and stress of serious illness. To assess whether the role of quality of life (QoL) indices, patient-reported outcome measures and PC have been studied in patients with calciphylaxis, we performed a systematic literature review. Several databases were searched from inception to October 2016 according to modified Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. We searched for papers on calciphylaxis that mentioned the symptoms and supportive needs of patients, QoL or outcome measures to report symptom severity, and the involvement of PC. Twelve papers met the inclusion criteria. Reported patient symptoms included pain, skin lesion resolution and pruritus, with the first being the most frequently reported. Four papers measured pain using a previously verified patient-reported outcome measure, including the Visual Analogue Scale. One paper used a verified QoL measure, the Dermatology Quality of Life Index. No tool was used consistently. Eight papers reported the use of hospice care or PC in the treatment of calciphylaxis. No outcome measure was used to prompt PC involvement. Overall, QoL indices, patient-reported outcome measures and PC are underreported in the treatment of calciphylaxis. PC may be a resource to assist in symptom management and adaptive coping strategies for patients from the onset of disease.

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“…More recently, encouraging preliminary results have been obtained with intravenous administration of sodium thiosulfate (STS). 31,39,[42][43][44] Although good response to STS is typically heralded by rapid improvement of the cutaneous pain, complete resolution of the skin lesions can take up to several months. 36,42 Possible complications of this therapy include the development of metabolic acidosis.…”

Section: Calciphylaxismentioning

confidence: 99%

Challenging Mimickers of Primary Systemic Vasculitis

Miloslavsky¹,

Stone²,

Unizony³

2015

Rheumatic Disease Clinics of North America

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Successful Treatment of Calciphylaxis with Intravenous Sodium Thiosulfate in a Nonuremic Patient: Case Report and Review of Therapy Side Effects

Abstract: Based on this case report, IV STS can improve refractory calciphylaxis in nonuremic patients. However, literature on the subject remains scarce. Careful monitoring for adverse transient side effects is advised.

Cited by 15 publications

References 10 publications

Pathogenesis and management of vascular calcification in CKD and dialysis patients

Pathogenesis and management of vascular calcification in CKD and dialysis patients

Underreported use of palliative care and patient-reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review

Challenging Mimickers of Primary Systemic Vasculitis

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