Successful Treatment of Cannabinoid Hyperemesis Syndrome with Topical Capsaicin

Moon, Andrew M.; Buckley, Sarah; Mark, Nicholas M.

doi:10.14309/crj.2018.3

Cited by 37 publications

(50 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These mechanisms attempt to describe the symptoms associated with CHS. CHS occurs in chronic marijuana smokers and is characterized by abdominal pain associated with intractable nausea and vomiting, often relieved by hot showers or smoking cessation [ 3 ]. Proposed mechanisms on a cellular level include G-coupled CB (CB 1 and CB 2 ) receptors located throughout the body producing various effects, i.e.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Small bowel intussusception in marijuana users

Kakish

Alaoudi

Welch

et al. 2020

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Intussusception occurs when one portion of bowel ‘telescopes’ into another due to a lead point created by a range of benign or pathologic process. Intussusception mostly occurs in children. Although adult intussusception (AI) is rare, accounting for <5% of intestinal obstructions, it is more concerning in adults as malignancy accounts for nearly 65% of lead points in AI. Patients present with severe abdominal pain concerning for an acute abdomen along with a degree of bowel obstruction. We have experienced a total of 11 patients within recent years presenting with symptoms of an acute abdomen due to AI. None of these patients were found to have a pathologic process creating a lead point. However, we found that all of them were marijuana users. In this report, we compare their management, hospital course and review of the literature discussing proposed mechanisms that suggest an association between cannabis and intussusception.

show abstract

Section: Discussionmentioning

confidence: 99%

“…chronic pain, chemotherapy-induced nausea, sleep disorders) [ 2 ], it seems practical to believe that marijuana use will continue to increase. Chronic marijuana use has led to patients presenting with complaints of nausea, vomiting and abdominal pain; an entity known as cannabinoid hyperemesis syndrome (CHS) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Small bowel intussusception in marijuana users

Kakish

Alaoudi

Welch

et al. 2020

Journal of Surgical Case Reports

View full text Add to dashboard Cite

show abstract

“…TRPV1 is a nonselective cation channel with calcium preference; it opens to ligand binding or stimulation. There is a high density of TRPV1 receptors in the area postrema known as the “trigger zone” for emesis [22]. Endocannabinoids (anandamide) along with exogenous cannabinoids (cannabidiol [CBD], cannabidivarin) are TRPV1 agonists [23, 24].…”

Section: Resultsmentioning

confidence: 99%

“…A summary of these studies appears in Table 2 [6, 7, 10, 19, 22, 54, 94, 97, 99, 101, 105, 111, 113, 114, 116, 117, 121, 126, 127, 132-173]. …”

Section: Clinical Considerationsmentioning

confidence: 99%

Cannabinoid Hyperemesis

Pergolizzi Jr.,

LeQuang,

Bisney

2018

Med Cannabis Cannabinoids

View full text Add to dashboard Cite

Cannabinoid hyperemesis syndrome (CHS) is a paradoxical condition in which a long-term cannabis user suffers an episode of intractable vomiting that may last days separated by longer asymptomatic periods of weeks or months. Cannabinoids are often utilized for their antiemetic properties, so CHS can be a puzzling condition, and the diagnosis of CHS may be disputed by patients. Unlike other cyclic vomiting syndromes, CHS can be relieved by hot showers or topical capsaicin. Abstinence from cannabinoids causes CHS to resolve, sometimes in a matter of days or hours. Marijuana users as well as many clinicians are not aware of CHS, and patients may undergo unnecessary tests, scans, and other procedures to get an accurate diagnosis. Symptoms may be severe enough to require hospitalization. With liberalization of marijuana laws and favorable public opinion about the healing properties of cannabis, CHS may be more frequently observed in clinical practice.

show abstract

“…By binding to TRPV1 receptors, topical capsaicin decreases the release of substance P from nerve endings, thereby decreasing nausea and vomiting in CHS. These studies suggest a role for substance P in the anti-emetic pathway [20].…”

Section: Discussionmentioning

confidence: 99%

Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome

Parvataneni

Varela

Vemuri-Reddy

et al. 2019

Cureus

View full text Add to dashboard Cite

Cannabis hyperemesis syndrome (CHS) is a clinical syndrome associated with prolonged and regular cannabis use. CHS is characterized by recurrent episodes of intractable nausea and vomiting. Given the overlap with other medical conditions and the frequent delay in diagnosis, finding an effective anti-emetic regimen for symptomatic control of CHS can be challenging. We report a case study where aprepitant (Emend) was successfully used as an anti-emetic in the treatment of CHS when all other common anti-emetics failed.

show abstract

Successful Treatment of Cannabinoid Hyperemesis Syndrome with Topical Capsaicin

Cited by 37 publications

References 18 publications

Small bowel intussusception in marijuana users

Small bowel intussusception in marijuana users

Cannabinoid Hyperemesis

Emerging Role of Aprepitant in Cannabis Hyperemesis Syndrome

Contact Info

Product

Resources

About