Successful treatment of cardiac haemangiomas with oral propranolol: a case series of two patients

Polymerou, Ioannis; Ojala, Tiina; Bonou, Pipina; Martelius, Laura; Tzifa, Aphrodite

doi:10.1093/ehjcr/ytz093

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…Biopsy of the mass was crucial to establish the final diagnosis, displaying typical morphological and immunohistochemical features and the absence of nuclear atypia or proliferation. The benign diagnosis and the impossibility of surgically resecting the masses prompted conservative therapy with oral propranolol, based on the evidence that this drug has induced regression of neonatal cardiac hemangiomas ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

What Is Hidden Behind Inferior Negative T Waves

et al. 2019

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Negative T waves in the inferior leads in an asymptomatic 17-year-old female patient prompted a diagnostic evaluation disclosing the presence of multiple cardiac glomangiomas. The combination of different imaging modalities (echocardiography, magnetic resonance, and positron emission tomography/computed tomography) and myocardial biopsy was crucial to establishing the correct diagnosis. ( Level of Difficulty: Advanced. )

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Section: Discussionmentioning

confidence: 99%

What Is Hidden Behind Inferior Negative T Waves

et al. 2019

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“…Tumor histology is the most significant predictor for mortality [ 9 ]. Alternative approaches, such as medical treatment with propranolol, due to having been established for a long time in the treatment of skin hemangioma, have been reported [ 10 ]. However, their efficacy and long-term outcomes are uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…In cases, where the tumor is unresectable or has low chance of malignancy, long-term stability without obstruction or compression of adjacent structures has been observed [ 11 ]. Hemangiomas can be treated with beta-blockers, which have shown a decrease in tumor volume [ 10 , 12 ]. Heart transplantation is considered as a last resort for the treatment of primary non-operable benign cardiac tumors [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Right ventricular outflow tract obstruction by cardiac hemangioma in asymptomatic patient

Kaewboonlert,

Chunharas,

Pluthikarmpae

et al. 2024

Journal of Surgical Case Reports

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Ventricular hemangiomas are rare benign tumors, pose diagnostic and therapeutic complexities. We report a case of a 52-year-old female with essential hypertension who developed a systolic ejection murmur during a hypertension clinic visit. The echocardiogram revealed a hyperechoic mass obstructing the right ventricular outflow tract, causing enlargement of the right atrium and ventricle, with a reduction in the right ventricular ejection fraction. Due to the risk of death, the patient underwent an emergency surgical resection along with tricuspid valve replacement. Postoperative recovery was uneventful, and subsequent cardiac magnetic resonance imaging showed an improvement in ejection fraction without residual tumor. This case highlights the diagnosis and therapeutic complexities of ventricular hemangiomas. With this report, we aim to provide a comprehensive review of ventricular hemangiomas and to enhance understanding of this condition for improved patient care.

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“…Clinically, propranolol is the drug of choice for the treatment of liver or skin haemangiomas, and there have been successful cases of oral propranolol in the treatment of infant cardiac haemangiomas. 9 , 10 However, there is no alternative treatment for adult cardiac haemangioma except surgery. Many scholars believe that cardiac haemangioma has the possibility of embolism, rupture and sudden death, therefore, in symptomatic children and adults, surgical resection is recommended.…”

Section: Discussionmentioning

confidence: 99%

Right ventricular haemangioma as a rare cause of chest pain: a case report

Tang

Jian

Yang

et al. 2021

European Heart Journal - Case Reports

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Background Cardiac haemangioma is a rare primary cardiac tumour. Most patients with cardiac haemangioma have no typical symptoms, and some may present with non-specific manifestations, such as shortness of breath, heart palpitations, or cardiac insufficiency, making it difficult to distinguish cardiac haemangioma from other diseases. We report a case of cardiac haemangioma that present with chest pain. This haemangioma was finally completely excised to relieve the patient’s symptoms and a avoid poor prognosis. Case summary A 14-year-old boy presented with an intermittent and progressive non-exertional chest pain for 2 weeks. Echocardiography showed a space-occupying mass at the right ventricular apex, which was later confirmed by computed tomography angiography and magnetic resonance imaging (MRI). The mass was successfully resected, and postoperative pathology confirmed a cardiac cavernous haemangioma. The patient had an uneventful postoperative recovery at the 8-month follow-up. Discussion Cardiac haemangioma is a benign tumour with no typical clinical manifestations, and very few patients may present with chest pain. Preoperative echocardiography, computed tomography, and MRI are helpful for diagnosis, and surgery can relieve symptoms and may improve the prognosis of patients with cardiac haemangioma.

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Successful treatment of cardiac haemangiomas with oral propranolol: a case series of two patients

Cited by 5 publications

References 19 publications

What Is Hidden Behind Inferior Negative T Waves

What Is Hidden Behind Inferior Negative T Waves

Right ventricular outflow tract obstruction by cardiac hemangioma in asymptomatic patient

Right ventricular haemangioma as a rare cause of chest pain: a case report

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