Successful Treatment of Catheter-Related Sepsis and Extraluminal Catheter Thrombosis with Vancomycin and Fraxiparin without Catheter Removal

Use of Vancomycin-Containing Lock or Flush Solutions for Prevention of Bloodstream Infection Associated with Central Venous Access Devices: A Meta-Analysis of Prospective, Randomized Trials

“…Our search yielded 63 published reports (figure 1); 56 studies were excluded because they evaluated lock solutions other than vancomycin [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46], did not have a control group [47][48][49][50], used a lock solution for treatment rather than prevention [45,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65], did not use a randomized, controlled study design [66][67][68][69], assessed the utility of a lock solution for prevention of BSI with only 1 type of organism [70], were reviews [19,20,56,[71][72][73][74][75]...…”

Lack of antimicrobial activity of sodium heparin for treating experimental catheter-related infection due to Staphylococcus aureus using the antibiotic-lock technique

“…Heparin lock should be used when the risk of catheter thrombosis is high but not based on criteria of antimicrobial properties. If there is catheter thrombosis in addition to infection, fibrinolitics should be tried in an attempt to improve therapeutic efficacy of antibiotics [35,36].…”

The In Vitro Susceptibility of Biofilm Forming Medical Device Related Pathogens to Conventional Antibiotics

“…Removal of the device may be considered in at risk patients with 5-7 days of antimicrobial chemotherapy. In patients where the aim is to salvage the device therapy should continue for a period of 10-14 days [14,15]. S. aureus catheterrelated bloodstream infection required the use of intravenous -lactam antibiotics, for example, flucloxacillin and oxacillin, with first generation cephalosporins like cefazolin used on presentation of penicillin allergic patients if the isolated microorganism is deemed susceptible [16].…”