Successful treatment of eosinophilic pustular folliculitis with topical tacrolimus

Abstract

We present two cases of Eosinophilic pustular folliclulitis (EPF) who were successfully treated with topical tacrolimus. Indomethacin is the most frequently used agent for the treatment of EPF, however, tacrolimus ointment may become the treatment of choice for patients with EPF.

Treatment of eosinophilic pustulosis of infancy with topical tacrolimus

“…Topical tacrolimus ointment 0·03% proved to be highly effective in both cases, providing rapid improvement in the eruption and the pruritus. Previous reports have demonstrated the usefulness and rapid onset of action of topical tacrolimus 0·1% in the treatment of adult EPF 7 but to our knowledge this treatment has not previously been described in the infantile form.…”

Bullous eosinophilic cellulitis succession with eosinophilic pustular folliculitis without eosinophilia

“…It has been suggested that indomethacin, an inhibitor of cyclooxygenase activity, reduces the synthesis of an eosinophil chemotactic factor, which was isolated from skin in EPF 10 . Nowadays, topical tacrolimus ointment has been reported in the treatment of EPF 24–26 . However, no treatment modality has been reported to be consistently effective in this disease 10 …”

HIV Eosinophilic Folliculitis in Uganda

“…On one side, red hair melanin is characterized by high ratio of pheomelanin to eumelanin, 4 and it is well known that pheomelanin is a risk factor for skin cancer. On one side, red hair melanin is characterized by high ratio of pheomelanin to eumelanin, 4 and it is well known that pheomelanin is a risk factor for skin cancer.…”