Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature

Ueda, Kosuke; Suekane, Shigetaka; Chikui, Katsuaki; Nakiri, Makoto; Moriya, Fukuko; Hayashi, Tokumasa; Miyajima, Jiro; Matsuoka, Kei

doi:10.3892/mco.2012.5

Cited by 5 publications

(2 citation statements)

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“…Erythrocytosis related with RCC is a secondary condition and is a rare event, occurring in no more than 5% RCC patients [ 7 ]; almost all cases of erythrocytosis occur in patients with clear cell renal cell carcinoma (ccRCC) [ 8 ]. Flank discomfort or pain, gross hematuria, flank mass, and weight loss can be observed in patients with chRCC; other symptoms include renal dysfunction, proteinuria, and pain from metastatic sites [ 9 – 11 ].…”

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confidence: 99%

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera

et al. 2017

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BackgroundErythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma.Case presentationWe report a case of a young man suffering from a giant (22-cm) mass on his left kidney. Because of a history of polycythemia vera, the patient had been treated for the condition for 9 years. Radical nephrectomy was successfully performed, and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell carcinoma. Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. Further examination and analysis were performed, and we finally attributed his erythrocytosis to chromophobe renal cell carcinoma.ConclusionsChromophobe renal cell carcinoma could cause erythrocytosis, but the clear-cut mechanism needs further research. Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.

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Section: Introductionmentioning

confidence: 99%

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera

et al. 2017

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“…Patients with RCC manifesting polycythemia have been rarely seen and the EPO level could be used as a tumor marker in these groups of patients. It has been founded that EPO level is correlated with grade and stage of RCC that equip prognostic information [4,5]. The production of EPO in normal kidneys occurs in the peritubular cells and it is controlled by oxygen sensor in epithelial cells in the proximal tubules [6].…”

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Renal Cell Carcinoma with Polycythemia

.¹,

.²,

.³

2021

amj

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Renal cell carcinoma (RCC) is the most common renal tumor and participates in about 80-85% of primary renal tumors. It is usually diagnosed incidentally during the evaluation for other medical problems; or it may be presented with gross hematuria, loin mass or pain. However, it infrequently presents as a paraneoplastic syndrome (PNS) which includes, hypertension, hypercalcemia, and abnormal liver function. A 75-year-old gentleman presented with an incidental left renal mass following the evaluation of the left loin pain with headache and dizziness. The patient had a history of hypertension for 10 years on control medical therapy and no history of smoking or chronic obstructive airway disease. The complete blood picture was showed a marked elevation in hemoglobin 21.7 g/dl and hematocrit level 65%. Ultrasound was showed left renal mass and a computerized tomography scan was showed the enhancement in the left renal mass picture suggestive of RCC. After phlebotomy of 2 units of blood, the patient underwent radical nephrectomy, then the histopathology was reported clear cell type RCC Fuhrman nuclear grading system II. At 2 months following surgery, the patient's hemoglobin level and hematocrit were returned to normal. The pathogenesis of PNS may be due to an abnormal immune system response to a cancerous cell. There is a wide range of the PNS concerning RCC including non-specific constitutional features for example; cachexia, weight loss, and fever, and specific metabolic and biochemical disorders (i.e. hypercalcemia, non-metastatic hepatic dysfunction, amyloidosis, etc.). PNS is often unrecognized but polycythemia should be considered important biomarkers in RCC, therefore, it can be used as a tumor marker in the diagnosis and follow-up of the patient after surgery.

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Kurukkal¹,

Al-Busaidy²

2015

Urological Cancer Management

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Successful treatment of erythropoietin-producing advanced renal cell carcinoma after targeted therapy using sunitinib: Case report and review of the literature

Cited by 5 publications

References 21 publications

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera

Renal Cell Carcinoma with Polycythemia

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