Successful Treatment of Eyelid Hemangioma With Prednisone

Venecia, Guillermo de; Lobeck, Charles C.

doi:10.1001/archopht.1970.00990040100024

Cited by 42 publications

(4 citation statements)

References 17 publications

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“…That systemic administration of cortico steroids may lead to involution of haeman giomas was discovered when they were used in attempts to control the tendency to bleed in children with thrombocytopenia and giant haemangiomas [Katz, 1965], Good results were later reported in cases with and with out thrombocytopenia IZarem and Edgerton, 1967;Fost and Esterly, 1968;Katz, and Askin, 1968;de Venecia and Lobeck, 1970;Hiles and Pilchard, 1971;Henderson, 1973;Steahly and AImquist, 1977].…”

Section: Discussionmentioning

confidence: 99%

Haemangio-Endothelioma of the Orbit

Bergström¹,

Enoksson²,

Gamstorp³

et al. 1978

Ophthalmologica

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Section: Discussionmentioning

confidence: 99%

Haemangio-Endothelioma of the Orbit

Bergström¹,

Enoksson²,

Gamstorp³

et al. 1978

Ophthalmologica

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“…15 Other authors have also reported varying degrees of success with steroid therapy. [16][17][18][19][20][21][22] The mechanism of steroid action is unknown but may include improved sensitization of the vascular lesion to vasoactive substances, interaction with hormonal agents such as estradiol, or inhibition of angiogenesis. 23,24 Steroid inhibition of angiogenesis may be further enhanced by the presence of heparin.…”

Section: Otolaryngology-head and Neck Surgerymentioning

confidence: 99%

“…More recent studies suggest that only 30% of hemangiomas respond dramatically to high‐dose oral systemic corticosteroids (2 to 3 mg/kg/day), 40% have a doubtful response that is not easily differentiated from the expected process of natural evolution, and 30% do not respond at all 15 . Other authors have also reported varying degrees of success with steroid therapy 16‐22 . The mechanism of steroid action is unknown but may include improved sensitization of the vascular lesion to vasoactive substances, interaction with hormonal agents such as estradiol, or inhibition of angiogenesis 23,24 .…”

mentioning

confidence: 99%

Treatment of massive or life‐threatening hemangiomas with recombinant α_2a‐interferon

Bauman

Burke

Smith

1997

Otolaryngol.--head neck surg.

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OBJECTIVE: To assess the response of massive, life-threatening, or function-impairing hemangiomas in pediatric patients receiving daily α2a-interferon subcutaneously. METHODS: The effect of 3 or more months of subcutaneous α2a-interferon (3 mU/m2) was prospectively evaluated in 10 patients with hemangiomas necessitating medical intervention. Hemangioma characteristics and extent were initially assessed by radiographic imaging in all but one patient. α2a-interferon tolerance was monitored, and reduction in hemangioma size was recorded as marked (>50%), moderate (25% to 50%), or minimal (<25%). RESULTS: Hemangiomas were apparent at birth in 8 of 10 patients, and α2a-interferon was initiated at a median age of 4.5 months. Symptoms necessitating therapeutic intervention included congestive heart failure, airway obstruction, dysphagia, infection, failure to thrive, external auditory canal occlusion, visual axis impairment, and severe facial deformity. Four patients received treatment before referral that included systemic steroids ( n = 2), intralesional steroids ( n = 1), or surgical/taser excision ( n = 2). α2a-Interferon therapy was well tolerated. Most patients had a temporary elevation in body temperature during the first month of therapy. One patient with anorexia required nasogastric feedings and a temporary reduction in her α2a-interferon dose. An additional patient with irritability was withdrawn from the study at his parents' request even though this symptom persisted after drug cessation. Hemangioma response to α2a-interferon was marked in six patients, moderate in two, and minimal in one whose lesion had features suggestive of a vascular malformation. Early signs of involution were usually evident within 6 weeks and often heralded by cutaneous blanching. α2a-Interferon therapy was concluded in four patients after a mean duration of 20 months. CONCLUSIONS: Daily subcutaneous α2a-interferon is well tolerated in pediatric patients and appears effective in hastening involution of symptomatic hemangiomas. A significant response is unlikely in lesions with features suggestive of a vascular malformation.

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“…Case 8. This boy was born with a capillary hemangioma of the lateral two thirds of the left upper eyelid.…”

Section: Case Reportsmentioning

confidence: 99%

The management of hemangiomas of the eyelid and orbit

et al. 1984

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The growth of hemangiomas of the orbital region varies greatly; it is unpredictable. Most lesions never reach sufficient size to impair vision; a few, however, may grow sufficiently to cause disastrous complications. Nine children with complete or partial occlusion of the vision by hemangioma of one eye are reported. (Functional vision was preserved only in those patients who had early subtotal excision of the eyelid hemangioma.) Two children with complete occlusion developed amblyopia in the involved eye. One had optic nerve atrophy. One of the four children with partial occlusion of vision had a permanent decrease in visual acuity. Of the remaining three children with normal vision, two had been operatively treated early, and one had unusually rapid involution of the hemangioma. We recommend that when a child has complete or partial visual occlusion due to hemangioma, subtotal or total excision of the hemangioma should be carried out within 1 week of the onset of visual occlusion to prevent amblyopia.

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Successful Treatment of Eyelid Hemangioma With Prednisone

Cited by 42 publications

References 17 publications

Haemangio-Endothelioma of the Orbit

Haemangio-Endothelioma of the Orbit

Treatment of massive or life‐threatening hemangiomas with recombinant α_2a‐interferon

The management of hemangiomas of the eyelid and orbit

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Successful Treatment of Eyelid Hemangioma With Prednisone

Cited by 42 publications

References 17 publications

Haemangio-Endothelioma of the Orbit

Haemangio-Endothelioma of the Orbit

Treatment of massive or life‐threatening hemangiomas with recombinant α2a‐interferon

The management of hemangiomas of the eyelid and orbit

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Product

Resources

About

Treatment of massive or life‐threatening hemangiomas with recombinant α_2a‐interferon