Successful Treatment of Facial Atrophic Acne Scars by Fractional Radiofrequency Microneedle in Vietnamese Patients

Kim, Cuc Nguyen Thi; Thi, Lan Pham; Van, Thuong Nguyen; Minh, Phuong Pham Thi; Nguyet, Minh Vu; Thi, Mai Le; Huu, Nghi Dinh; Hau, Khang Tran; Gandolfi, Marco; Satolli, Francesca; Feliciani, Claudio; Vojvodić, Aleksandra; Tirant, Michael; Lotti, Torello

doi:10.3889/oamjms.2019.002

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…Hyperpigmentation of the skin at the needle insertion and exit points was also observed here as in previous studies 31,34,35 . This is a common effect observed in many energy‐based skin therapies and is an unpredictable process associated with moderate tissue injury 40–43 . This needs to be further explored if this technology is to be directed for treating skin.…”

Section: Discussionsupporting

confidence: 79%

In vivo electrochemical lipolysis of fat in a Yucatan pig model: A proof of concept study

et al. 2022

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Objectives Traditional fat contouring is now regularly performed using numerous office‐based less invasive techniques. However, some limitations of these minimally invasive techniques include high cost or limited selectivity with performing localized contouring and reduction of fat. These shortcomings may potentially be addressed by electrochemical lipolysis (ECLL), a novel approach that involves the insertion of electrodes into tissue followed by application of a direct current (DC) electrical potential. This results in the hydrolysis of tissue water creating active species that lead to fat necrosis and apoptosis. ECLL can be accomplished using a simple voltage‐driven system (V‐ECLL) or a potential‐driven feedback cell (P‐ECLL) both leading to water electrolysis and the creation of acid and base in situ. The aim of this study is to determine the long‐lasting effects of targeted ECLL in a Yucatan pig model. Methods A 5‐year‐old Yucatan pig was treated with both V‐ECLL and P‐ECLL in the subcutaneous fat layer using 80:20 platinum:iridium needle electrodes along an 8 cm length. Dosimetry parameters included 5 V V‐ECLL for 5, 10, and 20 minutes, and −1.5 V P‐ECLL, −2.5 V P‐ECLL, −3.5 V P‐ECLL for 5 minutes. The pig was assessed for changes in fat reduction over 3 months with digital photography and ultrasound. After euthanasia, tissue sections were harvested and gross pathology and histology were examined. Results V‐ECLL and P‐ECLL treatments led to visible fat reduction (12.1%–27.7% and 9.4%–40.8%, respectively) and contour changes across several parameters. An increased reduction of the superficial fat layer occurred with increased dosimetry parameters with an average charge transfer of 12.5, 24.3, and 47.5 C transferred for 5 V V‐ECLL for 5, 10, and 20 minutes, respectively, and 2.0, 11.5, and 24.0 C for −1.5 V P‐ECLL, −2.5 V P‐ECLL, −3.5 V P‐ECLL for 5 minutes, respectively. These dose‐dependent changes were also evidenced by digital photography, gross pathology, ultrasound imaging, and histology. Conclusions ECLL results in selective damage and long‐lasting changes to the adipose layer in vivo. These changes are dose‐dependent, thus allowing for more precise contouring of target areas. P‐ECLL has greater efficiency and control of total charge transfer compared to V‐ECLL, suggesting that a low‐voltage potentiostat treatment can result in fat apoptosis equivalent to a high‐voltage DC system.

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Section: Discussionsupporting

confidence: 79%

In vivo electrochemical lipolysis of fat in a Yucatan pig model: A proof of concept study

et al. 2022

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“…83 PIH was also not a point of concern, as it had a very low occurrence rate and persisted temporarily. 84 , 85 Interestingly, hypertrophic scarring in the same needle distribution of microneedling devices used, resembling a “tram-trek” pattern, was noted by several authors over bony facial features (temples, forehead, etc). 86 , 87 Extra caution is highly recommended over these treatment areas.…”

Section: Microneedlingmentioning

confidence: 91%

A Comprehensive Review of Non-Energy-Based Treatments for Atrophic Acne Scarring

Tam¹,

Khong²,

Tam³

et al. 2022

CCID

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Scarring is a dire consequence of acne vulgaris. Particularly, atrophic acne scarring is highly prevalent among young adults, and its physical and psychological effects can persist throughout their lives if left untreated. This literature review will analyze various non-energy-based approaches to treating atrophic acne scarring, emphasizing recent advances within the last 5 to 10 years. To accomplish this, we performed a PubMed search for various acne scar treatments such as chemical peels, dermabrasion, microdermabrasion, subcision, microneedling, punch techniques, dermal fillers, and thread lifting. Our findings and analysis show that there is no panacean solution to treating atrophic acne scars, which explains the evolving trend towards developing unique combinatorial treatments. Although a fair comparison of each treatment approach is difficult to achieve due to the studies’ varying sample sizes, strength of evidence, treatment execution, etc, there still remains a level of consensus on what treatments are well suited for particular scar types.

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“…4,5 The excisions of a large SN, mainly located on the scalp and face, are limited by soft tissue laxity and convex surfaces and may require reconstruction with a skin flap. 6 The pathogenetic management of the SN must eliminate hamartous sebocytes, acanthotic cells and the obliteration of the involved microvessels. The laser radiation must be appropriately absorbed by such target molecules as lipids, melanin, oxyhemoglobin, and vascular endothelial growth factor (VEGF).…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Sebaceous Nevus With Copper Vapor Laser

Ponomarev,

Topchiy,

Andrusenko

et al. 2023

J Lasers Med Sci

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Introduction: Sebaceous nevus (SN) is a benign skin hamartoma with a potent transformation in benign or malignant tumors in adolescents or adults. Due to the most common location in the esthetic zone, an SN makes patients seek a dermatologist for cosmetic concerns on the face or neck. The surgical excision of a large-sized SN in the esthetic zone may require reconstruction with a skin flap and be associated with recurrences and scar formation. Case Report: We describe the successful treatment of the large-sized neck SN with copper vapor laser (CVL) for the first time. A left-sided neck SN (linear size of 27 mm) in the 24-year-old Caucasian female completely resolved after eight CVL sessions. The settings were as follows: average power accounted for 0.8-1.0 W, with a ratio at green (511 nm) and yellow (578 nm) wavelengths of 3:2. The pulse duration was set as 20 nanoseconds, the repetition rate 16.6 kHz, the exposure time 200 ms, light spot diameter of 1 mm. The CVL treatment resulted in the complete disappearance of the SN without remote side effects such as hyperpigmentation, scarring or recurrences 24 months after the treatment. The patient was satisfied with the excellent cosmetic results. Conclusion: The CVL treatment of the SN provides the most relevant result due to the complete elimination of SN cells and the remodeling of the vascular bed supplying the involved areas.

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Successful Treatment of Facial Atrophic Acne Scars by Fractional Radiofrequency Microneedle in Vietnamese Patients

Cited by 11 publications

References 8 publications

In vivo electrochemical lipolysis of fat in a Yucatan pig model: A proof of concept study

In vivo electrochemical lipolysis of fat in a Yucatan pig model: A proof of concept study

A Comprehensive Review of Non-Energy-Based Treatments for Atrophic Acne Scarring

Successful Treatment of Sebaceous Nevus With Copper Vapor Laser

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