Successful treatment of giant mesenteric fibromatosis with surgery and tamoxifen: case report

Abstract

A 65-year-old man underwent excision of a giant mesenteric fibromatosis (MF) via combined splenectomy and partial transverse colectomy. Pathological examination confirmed the presence of MF, whereas genetic testing indicated that the tumor was sensitive to tamoxifen. Over a 1-year follow-up, no symptoms of abdominal discomfort or recurrence was noted.

Solitary mesenteric fibromatosis in a male patient: clinical case report

“…Desmoid fibroma is a soft tissue tumor that is histologically benign but locally aggressive; it originates from the fascia or muscular aponeurotic structures and shows a tendency to invade adjacent tissues [ 5 , 6 ]. Desmoid tumors are classified as extra-abdominal and abdominal.…”

Desmoid-type fibromatosis of the chest wall: a case report

“…Desmoid-type fibromatosis (DF), also known as deep fibromatosis or desmoid tumor, is an extremely rare neoplasm that develops from fascia and musculoaponeurotic tissue. DF accounts for approximately 3.5% of all fibrous tumors, with an annual incidence of approximately 2-4/million (1,2). It can occur in almost any anatomical region but is most typically found in the abdomen, and it is especially common in females of childbearing age (3).…”

“…The tumors are characterized by slow progressive growth, local invasion, and local recurrence after surgical excision; however, they do not exhibit metastatic potential. The pathogeny of DF is diverse and uncertain, main causes including traumatic, abnormal level of estrogen and genetic factors, surgery is considered the most common cause (2).…”

“…In comparison, sporadic lesions are more likely to occur in the hip/buttock area, extremities, and shoulders (6). Studies have reported Case Report that the β-catenin pathway plays a critical role in sporadic lesions, with dysfunction of the CTNNB1 gene (2). DF of the chest wall, which is extra-abdominal, accounts for only 10-20% of all fibromatosis cases (7).…”