Successful treatment of hepatitis C virus infection in patients on anti‐epileptics or mood stabilizers using pharmacokinetic enhancers

Abstract

Co-administration of hepatitis C virus (HCV) direct-acting antivirals (DAAs) with antiepileptics or mood stabilizers with cytochrome P450 (CYP) and/or drug transportinducing properties is contraindicated due to concerns of subtherapeutic DAA levels that can lead to treatment failure and viral resistance. The recommended strategy is to change the interacting medication to a different agent that does not have inducing properties, but this is not always possible depending on the clinical scenario. We report on three patients who received DAAs for their HCV infection while remaining on the contraindicated anti-epileptic or mood stabilizer by utilizing CYP and drug transport inhibitors as pharmacokinetic enhancers to attempt to overcome the induction effects and maximize chances of achieving sustained virologic response (SVR).All patients achieved SVR despite the drug-drug interactions and there were no safety concerns. In patients facing this unique clinical quandary, the use of CYP and drug transport inhibitors appears to be a safe and possible strategy.

Virus-Induced Epilepsy vs. Epilepsy Patients Acquiring Viral Infection: Unravelling the Complex Relationship for Precision Treatment

“…Second-generation anticonvulsants or alternative dose/time regimens may provide better treatment outcomes and reduce the risk of drug interactions when treating patients with HIV infection and seizure disorders. The co-administration of DAAs with anti-epileptics or mood stabilizers with cytochrome P450 inducers can be managed using pharmacokinetic enhancers [187]. These enhancers can help minimize drug-drug interactions and improve the effectiveness of HCV treatment.…”