Successful treatment of hereditary factor VII deficiency presented for the first time with epistaxis in pregnancy: A case report

Aynaoğlu, Gülşah; Durdağ, Gülşen Doğan; Özmen, Batuhan; Söylemez, Feride

doi:10.3109/14767050903440463

Cited by 7 publications

(13 citation statements)

References 7 publications

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“…Few cases of severe epistaxis during pregnancy were described in literature [2–8, 12] (Table 1). We excluded cases of epistaxis associated with nasal lesions, like granuloma gravidarum [9] and nasal polyp [13], or clotting disorders [14].…”

Section: Discussionmentioning

confidence: 99%

Management of Severe Epistaxis during Pregnancy: A Case Report and Review of the Literature

Piccioni¹,

Derme²,

Salerno³

et al. 2019

Case Reports in Obstetrics and Gynecology

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Background Epistaxis is a common problem during pregnancy. Few cases of severe epistaxis, not associated with nasal lesions or clotting disorders, were described in the literature. We reported a case of severe epistaxis in a pregnant patient, exploring all the different possible management options. Case A 33-year-old primigravida, who was 38 weeks pregnant, presented with spontaneous severe left-sided epistaxis. Her blood pressure was into normal ranges. Clotting disorders and nasal lesions were excluded. The patient clinical worsening, due to severe anemia, and the failure of conservative treatment have imposed an emergency caesarean section, with an immediate resolution of the nasal bleeding. Conclusion Treatment of severe epistaxis must always consider conservative measures first-line with early recourse to otolaryngologist. In general, delivery of the fetus is considered curative.

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Section: Discussionmentioning

confidence: 99%

Management of Severe Epistaxis during Pregnancy: A Case Report and Review of the Literature

Piccioni¹,

Derme²,

Salerno³

et al. 2019

Case Reports in Obstetrics and Gynecology

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“…A total of 58 pregnancies in 41 women were reported in the retrieved literature. 10 , 11 , 12 , 14 , 16 , 17 , 18 , 19 , 20 , 23 , 35 , 36 , 40 , 41 , 42 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 FVII:C levels were reported before or during early pregnancy in 18 women; seven had severe FVII deficiency. 11 , 14 , 16 , 17 , 19 , 36 , 47 , 48 , 49 , 50 , 51 , 52 , 55 , 56 Three studies measured changes in FVII:C levels in 11 pregnancies.…”

Section: Resultsmentioning

confidence: 99%

Reproductive health and hemostatic issues in women and girls with congenital factor VII deficiency: A systematic review

Kadir

Gomez

2022

Journal of Thrombosis and Haemostasis

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Background Congenital factor VII (FVII) deficiency is an inherited bleeding disorder, with heterogenous bleeding symptoms. Women with FVII deficiency face hemostatic challenges during menstruation, ovulation, and childbirth. This systematic review evaluated prevalence and management of bleeding symptoms associated with gynecological and obstetric issues in women with FVII deficiency. Methods Databases (BIOSIS Previews, Current Contents Search, Embase, and MEDLINE) were searched for studies reporting FVII deficiency and gynecological or obstetric issues in women. Articles were screened using Joanna Briggs Institute checklists and relevant data extracted. Results One hundred fourteen women were identified from 62 publications. Forty‐six women had severe deficiency (FVII:C < 5% or <5 IU/dl). Heavy menstrual bleeding (HMB) was the most common bleeding symptom (n = 94; 82%); hospitalization and urgent medical/surgical interventions for acute HMB episodes were required in 16 women (14%). Seven women reported ovarian bleeding (6%); other bleeding symptoms varied. Patient management was inconsistent and included hemostatic and hormonal treatments. Only four women (7%) reporting vaginal bleeding during pregnancy. Postpartum hemorrhage (PPH) occurred following 12/45 deliveries (27%; 5 [42%] requiring blood transfusion) and was not necessarily prevented by prophylaxis (8 women). Conclusion Women with congenital FVII deficiency have an increased risk of HMB, ovarian bleeding, and PPH, impacting quality of life. Recognition of a bleeding disorder as the cause is often delayed. Management of bleeding complications is heterogeneous due to lack of treatment guidelines. Harmonizing severity classification of FVII deficiency may help standardize treatment strategies and development of specific guidelines for these women.

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“…In one study, a patient with factor II deficiency was referred for convulsions because of intracerebral haemorrhage [9], but in our study, three patients with FII deficiency who received plasma products did not have any problem. Many centres prefer to manage FVII deficiency with replacement of rFVII [10]. Unfortunately in our centre, three patients who were FX deficient experienced intraventricular haemorrhage and intracranial haemorrhage despite of FFP prophylaxis.…”

Section: Referencesmentioning

confidence: 89%

Safety of human blood products in rare bleeding disorders in southeast of Iran

et al. 2012

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Successful treatment of hereditary factor VII deficiency presented for the first time with epistaxis in pregnancy: A case report

Abstract: FVIID, a rare cause of ante- and postpartum hemorrhages that may differently present by other hemorrhages (i.e.: epistaxis), can be optimally managed with replacement of rFVII.

Cited by 7 publications

References 7 publications

Management of Severe Epistaxis during Pregnancy: A Case Report and Review of the Literature

Management of Severe Epistaxis during Pregnancy: A Case Report and Review of the Literature

Reproductive health and hemostatic issues in women and girls with congenital factor VII deficiency: A systematic review

Safety of human blood products in rare bleeding disorders in southeast of Iran

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