Successful Treatment of Impetigo Herpetiformis With Oral Cyclosporine During Pregnancy

Imai, Nozomu

doi:10.1001/archderm.138.1.128

Cited by 53 publications

(29 citation statements)

References 4 publications

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“…Improvement of IH has been reported with calcium and vitamin D supplementation (1). In corticosteroidunresponsive severe cases, cyclosporine has been used successfully to treat IH (11). Case reports have demonstrated successful treatment of postpartum IH with oral retinoids (12) or psoralen plus ultraviolet light A (PUVA) (13).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Postpartum Impetigo Herpetiformis Presenting After a ”Skip” Pregnancy

Vaidya¹,

Kroumpouzos²,

Bercovitch³

2013

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 99%

Recurrent Postpartum Impetigo Herpetiformis Presenting After a ”Skip” Pregnancy

Vaidya¹,

Kroumpouzos²,

Bercovitch³

2013

Acta Derm Venerol

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“…Amniyotik erken membran rüptürü ve düşük doğum ağırlıklı bebek gözlenebilecek yan etkilerdir 11 . Oral siklosporin, İH tedavisinde faydalı olduğu belirtilen ikinci tedavi seçeneğidir 1,5,10 . Doza bağımlı olarak plasental membrandan geçebildiğinden gebelikte "C" kategorisindedir.…”

Section: Discussionunclassified

“…Mortalite ve morbiditesinin yüksek olması sebebiyle İH tanısı hızlı ve erken konulmalı, tedaviye hemen başlanmalıdır. Tedavide sistemik kortikosteroidler ve siklosporin A gibi etkili olduğu belirtilen farklı tedavi seçenekleri bulunmaktadır 5 . Intravenöz immunglobulin (IVIG), steroid ve diğer immunsupresif ajanlarda gözlenen yan etkilerin olmadığı güvenilir bir tedavi seçeneğidir.…”

Section: Gi Riflunclassified

Tedaviye Dirençli İmpetigo Herpetiformis'te İntravenöz İmmunglobulin Tedavisinin Etkinliği: Olgu Sunumu

...

2012

Turkderm

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Özetİmpetigo herpetiformis (İH), yüksek fetal morbidite ve mortaliteye sahip, bazen gebeliğin sonlandırılmasını gerektirebilen bir hastalıktır. Etkili olduğu belirtilen farklı tedavi seçenekleri bulunmaktadır. Yirmi üç yaşında, psoriazis öyküsü olan 25 haftalık gebe olgu, ani başlangıçlı jeneralize püstüler döküntülerle başvurdu. Klinik bulgular ve histopatolojik değerlendirme ile İH tanısı konuldu. Sistemik prednizolon (2 mg/kg/gün) üç hafta süreyle uygulandı. Yanıt olmadığı için siklosporin A (3mg/kg/gün) ilave edildi. İki hafta siklosporin A ve sistemik prednizolon kombine kullanılmasına rağmen deri bulguları gerilemedi. Tedavilere ek olarak 30. Sum maryImpetigo herpetiformis (IH), if left untreated, is associated with a high rate of perinatal morbidity and mortality and may lead to the decision of termination of pregnancy. There are various and effective therapeutic agents available for the treatment of the disease. A 23-year-old woman with a history of plaque psoriasis presented with a sudden generalized pustular eruption on the 25th week of her first gestation. The diagnosis was made based on the clinical and histopathological findings. The patient was treated with systemic prednisolone (2 mg/kg/d) first and, cyclosporine A (3 mg/kg/d) was added to the treatment after two weeks because prednisolone was not effective alone. The lesions did not regress despite four weeks of combined treatment with prednisolone and cyclosporine. Intravenous immunoglobuline (IVIG) (0.3 g/kg/d, 6 days) was added on the 30th week of gestation and resulted in regression of cutaneous rashes. On the 33rd week of gestation, IVIG (0.7 g/kg/d, 3 days) was repeated due to reactivation of pustules, and an improvement was observed. In this case report, we called attention to IVIG therapy in IH, for having the pregnancy continued enough for the fetal maturation before the delivery. (Turk derm 2012; 46: 104-6

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“…Como en el caso presentado, cuando este esquema fracasa en el control de la enfermedad y/o aparecen efectos colaterales que otorgan mayor riesgo al binomio madre-hijo (diabetes), se ha aconsejado el uso de ciclosporina por vía oral con buenos resultados materno-fetales 8 .…”

Section: Discussionunclassified

Impétigo herpetiforme recurrente: manejo exitoso con ciclosporina

Valdés

Núñez²,

Pedraza

et al. 2005

Rev. méd. Chile

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esde que Hebra, en 1872, describió por primera vez esta enfermedad de rara ocurrencia 1 , el pronóstico feto-materno del impétigo herpetiforme (IH) ha presentado una gran mejoría, secundaria esencialmente al apoyo clínico multidisciplinario al binomio madre-hijo y a la corticoterapia. Cuando estas medidas son insuficientes para el control de la enfermedad se ha planteado la asociación terapéutica con ciclosporina.Se presenta un caso clínico de impétigo herpetiforme recidivado en un segundo embarazo y refractario al tratamiento de apoyo multisistémico y corticoidal, por lo que se decidió asociar terapia con ciclosporina, obteniéndose una buena respuesta clínica materna y un buen resultado perinatal. CASO CLÍNICOPaciente de 24 años, con antecedentes de psoriasis en control desde los 12 años; fórmula obstétri-Rev Méd

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Successful Treatment of Impetigo Herpetiformis With Oral Cyclosporine During Pregnancy

Cited by 53 publications

References 4 publications

Recurrent Postpartum Impetigo Herpetiformis Presenting After a ”Skip” Pregnancy

Recurrent Postpartum Impetigo Herpetiformis Presenting After a ”Skip” Pregnancy

Tedaviye Dirençli İmpetigo Herpetiformis'te İntravenöz İmmunglobulin Tedavisinin Etkinliği: Olgu Sunumu

Impétigo herpetiforme recurrente: manejo exitoso con ciclosporina

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