Successful treatment of indeterminate cell histiocytosis with low-dose methotrexate*

Fournier, John; Ingraffea, Adam; Pedvis-Leftick, Anita

doi:10.1111/j.1346-8138.2010.01148.x

Cited by 15 publications

(19 citation statements)

References 7 publications

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“…No established treatment for S100‐negative, CD1a‐positive histiocytosis is available at the present time. Our patient responded fairly well to combination therapy using MTX and prednisolone which is consistent with treatment for cutaneous ICH and LC histiocytosis . The absence of epidermotropism of the tumor cells may explain the ineffectiveness of PUVA therapy.…”

Section: Discussionsupporting

confidence: 77%

“…Our patient responded fairly well to combination therapy using MTX and prednisolone which is consistent with treatment for cutaneous ICH and LC histiocytosis. 5,6 The absence of epidermotropism of the tumor cells may explain the ineffectiveness of PUVA therapy. Further study is required to establish the detailed nature of this rare histiocytosis including the most appropriate treatment which may involve combination therapy using oral MTX and corticosteroid.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous S100‐negative, CD1a‐positive histiocytosis successfully treated with combination therapy of oral methotrexate and corticosteroid

Takahashi

Kaneta

Nomura

et al. 2015

The Journal of Dermatology

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S100-negative, CD1a-positive histiocytosis is a rare histiocytic disorder characterized by proliferation of histiocytic cells possessing a phenotype of epidermal Langerhans cells except for the lack of S100 expression and Birbeck granules. We report the case of a Japanese man suffering from S100-negative, CD1a-positive histiocytosis. The patient showed numerous smooth erythematous 5-10-mm papules/nodules on most of his body. The key histopathological feature was the presence of dermal infiltrates of non-epidermotropic S100-negative CD1a-positive mononuclear cells. No systemic involvement was detected. Initially bath-psoralen plus ultraviolet A therapy was effective, but the lesions became recalcitrant to this treatment. Methylprednisolone pulse therapy followed by low-dose methotrexate (up to 30 mg/week) in combination with prednisolone (15 mg/day) effectively controlled the skin lesions.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Cutaneous S100‐negative, CD1a‐positive histiocytosis successfully treated with combination therapy of oral methotrexate and corticosteroid

Takahashi

Kaneta

Nomura

et al. 2015

The Journal of Dermatology

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“…7,10,38,39 Responses to chemotherapeutic strategies or total skin electron beam therapy have been reported in multilesional skin disease, although relapses requiring additional therapy appear to be the rule. 1,6,35,40,41 (1) Skin, multilesional Observation (9) Spontaneous regression (2) Remission (1) NA (7) Partial regression (1) Progression (1) Death due to associated neoplasm (1) ND (5) Electrodessication (1) NA ND (1) Topical 5-FU/coal tar (1) Response (1) ND (1) PUVA or UVB (5) b Response (5) ND (5) Pravastatin (1) Improvement (1) ND (1) Thalidomide (3) Response (3) Remission (2) Death due to associated neoplasm (1) Chemotherapy (8) Response with multiple recurrences (7) Remission (4) Progressive (1) Death due to associated neoplasm (1) ND (3) Chemotherapy for associated neoplasm (5) NA Death due to associated neoplasm (3) ND (2) Total skin electron beam (2) Response (1) ND (2) Improvement and relapse (1) Lymph…”

Section: So Far a Clonal Relationship Between The Idcn And An Associmentioning

confidence: 99%

Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

et al. 2017

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Indeterminate dendritic cell neoplasm (IDCN) is an exceedingly rare and mostly cutaneous histiocytosis, frequently associated with other hematopoietic malignancies. We report 2 cases of multilesional cutaneous IDCN. A 55-year-old male with no associated malignancy and complete response to ultraviolet phototherapy; and a 72-year-old male with chronic myelomonocytic leukemia (CMML). Both cases showed histiocytoid cytology, positivity for CD1a and no expression of langerin or BRAF . With our patients, the literature describes 79 cases of IDCNs, including 65 (82%) with only skin involvement, 7 cases (9%) with involvement of skin and a second site, 5 cases (6%) involving lymph nodes only, 1 splenic lesion and 1 systemic disease. Seventeen cases (22%) were associated with other hematopoietic malignancies, most commonly CMML (6 cases), follicular lymphoma (4 cases) and acute myeloid leukemia (3 cases). All IDCNs associated with myeloid malignancies were limited to the skin, while most cases associated with lymphoma were limited to lymph nodes. Reported responses of cutaneous lesions to ultraviolet phototherapy are encouraging, while systemic chemotherapy is appropriate for clinically aggressive cases and treatment of associated malignancies. Recognition of the clinico-morphologic spectrum of IDCNs should prevent misdiagnoses and prompt investigation of possible associated neoplasms.

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“…IDCT usually presents with multiple papules on the trunk and extremities . Mostly, cases of facial involvement present with discrete papules or a solitary nodule . Interestingly, our patient presented with typical leonine facies with partial loss of eyebrows.…”

Section: Discussionmentioning

confidence: 69%

A case of indeterminate dendritic cell tumor presenting with leonine facies

Ivan

Curry

et al. 2015

J Cutan Pathol

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Successful treatment of indeterminate cell histiocytosis with low-dose methotrexate*

Cited by 15 publications

References 7 publications

Cutaneous S100‐negative, CD1a‐positive histiocytosis successfully treated with combination therapy of oral methotrexate and corticosteroid

Cutaneous S100‐negative, CD1a‐positive histiocytosis successfully treated with combination therapy of oral methotrexate and corticosteroid

Indeterminate dendritic cell neoplasm of the skin: A 2‐case report and review of the literature

A case of indeterminate dendritic cell tumor presenting with leonine facies

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