Successful Treatment of Infantile Subglottic Hemangioma With Oral Propranolol

Yuan, Chun; Moon, Cheong Jun; Yoon, Jong-Seo; Kim, Hyun Hee; Kim, Jin Tack; Lee, Joon Sung

doi:10.1177/0009922811410972

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…A follow-up retrospective study in France showed that propranolol effectively reduced 37 of 39 head and neck hemangiomas, and advocated propranolol as a first line treatment for head and neck hemangiomas. Since that time, there have been several successful reports of propranolol use for airway hemangiomas, either as part of a combined therapy with corticosteroids [2][3][4], or as isolated therapy [5][6][7][8]. Leboulangier published a series of 14 patients with subglottic hemangioma recalcitrant to other forms of treatment, all of whom responded to propranolol therapy initially [9].…”

Section: Introductionmentioning

confidence: 99%

Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated?

Siegel

Mehta

2015

International Journal of Pediatric Otorhinolaryngology

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Section: Introductionmentioning

confidence: 99%

Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated?

Siegel

Mehta

2015

International Journal of Pediatric Otorhinolaryngology

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“…Agents with reported activity in treating IHs include corticosteroids, interferon‐α, vinca alkaloids, and recently β‐blockers. Since the initial report of oral propranolol use for the treatment of IHs in 2008, there has been a flurry of case series describing topical and oral β‐blocker efficacy . Given propranolol's efficacy and immediate availability in an oral solution, it has rapidly been adopted as a first‐line therapy for IHs.…”

mentioning

confidence: 99%

Adverse Events in Young and Preterm Infants Receiving Topical Timolol for Infantile Hemangioma

Frommelt

Juern

Siegel

et al. 2016

Pediatric Dermatology

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In this cohort of at-risk infants, topical timolol appeared to provide safe treatment for IHs in full-term infants receiving a dose of less than 0.2 mg/kg/day, but infants with a PMA of less than 44 weeks and weight at treatment initiation of less than 2,500 g may be at risk of adverse events, including bradycardia, hypotension, apnea, and hypothermia. We recommend close monitoring of temperature, blood pressure, and heart rate in premature and low-birthweight infants with IHs at initiation of and during therapy with topical timolol.

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Diagnostic Techniques for Infantile Subglottic Hemangiomas: A Scoping Review

Ezeh,

Tesema,

Hasnie

et al. 2024

The Laryngoscope

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ObjectiveInfantile subglottic hemangioma (SGH) poses a risk of airway compromise if untreated. Traditionally, operative endoscopy (OH) diagnoses SGH, but since the discovery of beta‐blockers' efficacy in treating infantile hemangiomas (IHs) in 2008, and advances in endoscopic technology, nonoperative methods have emerged. This review identifies endoscopic practices for diagnosing and monitoring infantile SGH during the oral beta‐blocker treatment era.Data SourcesA comprehensive literature search in October 2022 and August 2023 covered PubMed, Embase, Cochrane Library, SCOPUS, and Web of Science.Review MethodsThe search was limited to English‐language studies published since 2008, considering this when propranolol was demonstrated as an effective treatment option for IH. The articles were screened for relevance based on predefined inclusion and exclusion criteria.ResultsAfter inclusion and exclusion criteria, sixty final studies were identified, describing 240 cases of infantile SGH. Most children were diagnosed using OE alone (73.3%; n = 176/240), 23.3% (n = 56/240) using office‐based laryngoscopy procedures (OBPs) followed by OE, 3.3% using OBP alone (n = 8/240). There were no reported diagnostic endoscopy‐related complications. Twenty‐nine studies described using endoscopy plus diagnostic imaging to either confirm an SGH lesion, characterize the extent of disease spread, or rule out other causes of presenting symptoms. The proportion of infants diagnosed with OE alone decreased from 2008 to 2023.ConclusionOperative endoscopy remains the SGH diagnostic standard, but OBP adoption is increasing. Further research is needed to determine the optimal SGH diagnosis and management approach.Level of EvidenceNA Laryngoscope, 2024

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Successful Treatment of Infantile Subglottic Hemangioma With Oral Propranolol

Cited by 4 publications

References 10 publications

Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated?

Open airway surgery for subglottic hemangioma in the era of propranolol: Is it still indicated?

Adverse Events in Young and Preterm Infants Receiving Topical Timolol for Infantile Hemangioma

Diagnostic Techniques for Infantile Subglottic Hemangiomas: A Scoping Review

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