Successful treatment of intra‐abdominal eumycotic mycetoma caused by Penicillium duponti in a dog

Abstract

A 2-year-old female neutered golden retriever was presented for investigation of an intra-abdominal mass. Computed tomography revealed a mass associated with the caudal pole of the right kidney. Incisional biopsy findings were consistent with eumycotic mycetoma. The mass was subsequently removed in conjunction with right ureteronephrectomy. Two years later, the dog re-presented with a splenic mass and fungal plaques located throughout the peritoneum. Splenectomy was performed and the mass was diagnosed as eumycotic mycetoma caused by Penicillium duponti. Indefinite systemic treatment with 10 mg/kg itraconazole orally once a day was initiated. Thirty-two months after the last surgery, there were no clinical signs apart from mild polydipsia. Haematology and biochemistry results were unremarkable. To the authors' knowledge, this is the first report of successful treatment of intra-abdominal eumycotic mycetoma with a combination of surgery and systemic antifungal therapy in the dog. Penicillium duponti has not apparently been reported to cause disease in animals or humans.

Unusual presentation and urinary tract obstruction due to disseminated intra-abdominal eumycetomas caused by Curvularia species in a dog

“…Eumycetomas are chronic pyogranulomatous lesions caused by moulds, frequently reported in humans living in tropical and subtropical environments (e.g. Madura Foot) but rarely in dogs [[1], [2], [3], [4], [5], [6]]. Usually restricted to subcutaneous tissues, there have been only two reports of cases involving intra-abdominal lesions in dogs [[4], [5], [6]].…”

“…Madura Foot) but rarely in dogs [[1], [2], [3], [4], [5], [6]]. Usually restricted to subcutaneous tissues, there have been only two reports of cases involving intra-abdominal lesions in dogs [[4], [5], [6]]. These were associated with the uterine stump and the caudal aspect of the right kidney, caused by Madurella mycetomatis and Penicillium duponti respectively [4,6].…”

“…Usually restricted to subcutaneous tissues, there have been only two reports of cases involving intra-abdominal lesions in dogs [[4], [5], [6]]. These were associated with the uterine stump and the caudal aspect of the right kidney, caused by Madurella mycetomatis and Penicillium duponti respectively [4,6]. In both cases, infection was attributed to contamination of the surgical wound post ovariohysterectomy dehiscence [4,6].…”

“…These were associated with the uterine stump and the caudal aspect of the right kidney, caused by Madurella mycetomatis and Penicillium duponti respectively [4,6]. In both cases, infection was attributed to contamination of the surgical wound post ovariohysterectomy dehiscence [4,6]. The case reported here is the first report of extensive intra-abdominal dissemination and associated lower urinary tract obstruction in a dog caused by eumycetomas of the Curvularia species.…”

Therapy of Non-Dermatophytic Mycoses in Animals

“…Thus, susceptibility was tested only for the latter isolate resulting in an inhibition zone of 30 mm, probably indicating that, contrary to the in vivo lack of activity, in vitro the fungus was still susceptible to the drug. More recently, Janovec et al [85] reported the successful treatment with itraconazole of a dog with visceral mycetoma caused by Penicillium duponti.…”