Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report

Lee, Seung Hyoung; Son, Young Hoon; Sohn, Soo Sang; Ryu, Seung Wan

doi:10.3892/etm.2014.1753

Cited by 20 publications

(13 citation statements)

References 20 publications

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“…A total of 200 cases of GI mucormycosis in non‐classical immunosuppressed or apparently immunocompetent hosts reported during 1948 through 2017 in English literature . The case details could be retrieved for 176 cases.…”

Section: Resultsmentioning

confidence: 99%

Gastrointestinal mucormycosis in apparently immunocompetent hosts—A review

Kaur

Ghosh

Rudramurthy

et al. 2018

Mycoses

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The diagnosis of gastrointestinal (GI) mucormycosis is always a challenge due to its non-specific clinical presentations and often diagnosed at autopsy. Recently increased number of GI mucormycosis has been reported in immunocompetent hosts and during 1948 through 2017, 200 cases of GI mucormycosis are available in literature. We could review 176 cases where case details were available. Majority (50.6%) of the cases were reported from Asia. The disease is nearly equally recorded in adults and paediatric population. The infection commonly affected the intestine (64.2%) followed by stomach (33%). A significant improvement in antemortem diagnosis was noted since 2001. Rhizopus species were the predominant (67.5%) aetiological agents. Amphotericin B was the most commonly used drug (93.4%). Despite improvement of antemortem diagnosis and therapy, the mortality was 60.5% and 67.5% in adults and children respectively. Combined medical and surgical therapy (reported in 47.8% patients) had significantly better survival rate than those receiving either of them. Analysing the clinical presentations, we propose to suspect GI mucormycosis in a malnourished/ dehydrated child (especially premature neonate) with history of exposure to broad-spectrum antibiotics or formula/spoon feeding and presenting with mass in abdomen, abdominal distension or bilious vomiting; and an adult presenting with abdominal distension, fever or GI bleed with underlying risk factors for mucormycosis.

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Section: Resultsmentioning

confidence: 99%

Gastrointestinal mucormycosis in apparently immunocompetent hosts—A review

Kaur

Ghosh

Rudramurthy

et al. 2018

Mycoses

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“…Malnutrition, gastric ulcers, severe systemic illness, age extremes, and immunosuppression are the typical predisposing conditions for gastrointestinal mucormycosis . Although gastric mucormycosis in patients with alcoholic liver cirrhosis has rarely been reported, alcoholism appears to be a risk factor of gastric mucormycosis . In literature, four cases of gastric mucormycosis in patients with alcoholism are reported .…”

Section: Discussionmentioning

confidence: 99%

“…Although gastric mucormycosis in patients with alcoholic liver cirrhosis has rarely been reported, alcoholism appears to be a risk factor of gastric mucormycosis . In literature, four cases of gastric mucormycosis in patients with alcoholism are reported . Ho et al reported that the ingestion of fungal spores and their germination may be harmful to a patient with alcoholism as ethanol may disrupt the activation of macrophages and dendritic cells, which play crucial role in the elimination of fungal spores.…”

Section: Discussionmentioning

confidence: 99%

Gastric mucormycosis: Diagnosis by imprint cytology

Tathe

Dani

Chawhan

et al. 2016

Diagnostic Cytopathology

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The fungi in the order of Mucorales commonly target diabetics and other immunocompromised hosts, producing fatal respiratory and or CNS infections. Gastrointestinal mucormycosis is uncommon and seldom diagnosed in living patients due to nonspecific clinical manifestations. We report a case of gastric mucormycosis in an immmunocompetent male patient, diagnosed by imprint cytology-a rare site and a rare setting. To the best of our knowledge, this is only the second report of gastric mucormycosis being diagnosed on cytology. As the disease is rapidly progressive and often fatal, early diagnosis is critical to the patient survival. Imprint cytology or brush cytology is extremely useful for the rapid diagnosis of gastric mucormycosis as these organisms are morphologically distinct. Familiarity with the cytomorphology of these organisms assists in the correct diagnosis of this disease. Diagn. Cytopathol. 2016;44:820-822. © 2016 Wiley Periodicals, Inc.

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“…An abdominal CT scan demonstrated circumferential gastric wall thickening and mucosal hyperenhancement, gastric pneumatosis, and portal venous gas concerning for EG (Figure 1). On the basis of these imaging findings, the patient was initially given broad empiric antimicrobial therapy with intravenous ciprofloxacin and metronidazole to cover typical enteric bacteria as well as liposomal amphotericin B in case she had gastrointestinal mucormycosis 3. An esophagogastroduodenoscopy showed extensive necrotic mucosa in the stomach (Figure 2).…”

Section: Case Reportmentioning

confidence: 99%

Emphysematous Gastritis in a Patient with Untreated Cyclic Vomiting Syndrome

Robinson

Sadowski

Eickhoff

et al. 2018

ACG Case Reports Journal

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Emphysematous gastritis (EG) is an uncommon and potentially fatal disease characterized by gastric pneumatosis in the setting of infection. While this disease has been described in the literature, it has not previously been identified as a potential complication of cyclic vomiting syndrome. We describe a patient with a history of cyclic vomiting syndrome who presented acutely ill and was found to have radiographic, endoscopic, and histologic evidence of EG. This case illustrates how an untreated functional bowel disorder can lead to severe and potentially fatal complications.

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Successful treatment of invasive gastric mucormycosis in a patient with alcoholic liver cirrhosis: A case report

Cited by 20 publications

References 20 publications

Gastrointestinal mucormycosis in apparently immunocompetent hosts—A review

Gastrointestinal mucormycosis in apparently immunocompetent hosts—A review

Gastric mucormycosis: Diagnosis by imprint cytology

Emphysematous Gastritis in a Patient with Untreated Cyclic Vomiting Syndrome

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