Successful treatment of inverted Takotsubo cardiomyopathy after severe traumatic brain injury with milrinone after dobutamine failure

Mrozek, Ségolène; Srairi, Mohamed; Marhar, Fouad; Delmas, Clément; Gaussiat, François; Abaziou, Timothée; Larcher, Claire; Atthar, Vincent; Menut, Rémi; Fourcade, Olivier; Geeraerts, Thomas

doi:10.1016/j.hrtlng.2016.06.007

Cited by 30 publications

(21 citation statements)

References 27 publications

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“…Milrinone could be a good alternative when inotropes are required in TCM and when dobutamine infusion is associated with tachycardia [52]. The use of milrinone has been proposed to augment the cerebral perfusion in TCM giving its combined inotropic and vasodilating properties [53].…”

Section: Choice Of Drugs For Post-sah Tcm Patientsmentioning

confidence: 99%

“…The use of milrinone has been proposed to augment the cerebral perfusion in TCM giving its combined inotropic and vasodilating properties [53]. Milrinone is a phosphodiesterase-III inhibitor that increases calcium influx in the myocardium which leads to increased cardiac contractility without βagonist action, resulting in less tachycardia [52] and myocardial oxygen consumption [54]. However, milrinone may induce hypotension as a result of peripheral vasodilatory property, which may require intensive hemodynamic monitoring during the management.…”

Section: Choice Of Drugs For Post-sah Tcm Patientsmentioning

confidence: 99%

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Takotsubo Cardiomyopathy as a Neurocardiogenic Injury after Subarachnoid Hemorrhage: Hemodynamics and Fluid Management

Mutoh¹,

Mutoh²,

Taki³

et al. 2017

Cardiomyopathies - Types and Treatments

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Takotsubo cardiomyopathy (TCM) is a life-threatening systemic disorder that may occur early after aneurysmal subarachnoid hemorrhage (SAH), but precise hemodynamics and fluid management remain unclear. Although TCM is often regarded as a reversible or self-limited phenomenon, it contributes significantly to morbidity and mortality of SAH patients, especially when it is complicated with other neurogenic injuries such as severe left ventricular dysfunction, pulmonary edema, and pneumonia. The purpose of this chapter is to introduce the current practice in intensive hemodynamic monitoring and goal-directed fluid management of post-SAH TCM using advanced hemodynamic devices based on our institutional protocol and the relevant literature and to evaluate their effects on clinical outcomes.

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Section: Choice Of Drugs For Post-sah Tcm Patientsmentioning

confidence: 99%

Section: Choice Of Drugs For Post-sah Tcm Patientsmentioning

confidence: 99%

Takotsubo Cardiomyopathy as a Neurocardiogenic Injury after Subarachnoid Hemorrhage: Hemodynamics and Fluid Management

Mutoh¹,

Mutoh²,

Taki³

et al. 2017

Cardiomyopathies - Types and Treatments

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“…In the clinical setting, however, the infusion of catecholamines such as noradrenaline and dobutamine may have limited effects and may aggravate cardiac failure due to massive stress hormone release, so‐called ‘catecholamine surge’ or ‘adrenergic storm’ caused by severe acute brain injury . There are also concerns of cerebral vasoconstriction even with the use of the most reliable vasopressor noradrenaline .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 In the clinical setting, however, the infusion of catecholamines such as noradrenaline and dobutamine may have limited effects and may aggravate cardiac failure due to massive stress hormone release, so-called 'catecholamine surge' or 'adrenergic storm' caused by severe acute brain injury. 9,10 There are also concerns of cerebral vasoconstriction even with the use of the most reliable vasopressor noradrenaline. 11 The phosphodiesterase-III inhibitor milrinone (MIL) may be an alternative option when inotropes are required but dobutamine is contraindicated due to tachycardia, left ventricular outflow obstruction or neurogenic cardiomyopathies.…”

mentioning

confidence: 99%

Acute cardiac support with intravenous milrinone promotes recovery from early brain injury in a murine model of severe subarachnoid haemorrhage

Mutoh

Nakamura

et al. 2017

Clin Exp Pharma Physio

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Early brain injury/ischaemia (EBI) is a serious complication early after subarachnoid haemorrhage (SAH) that contributes to development of delayed cerebral ischaemia (DCI). This study aimed to determine the role of inotropic cardiac support using milrinone (MIL) on restoring acute cerebral hypoperfusion attributable to EBI and improving outcomes after experimental SAH. Forty-three male C57BL/6 mice were assigned to either sham surgery (SAH-sham), SAH induced by endovascular perforation plus postconditioning with 2% isoflurane (Control), or SAH plus isoflurane combined with MIL with and without hypoxia-inducible factor inhibitor (HIF-I) pretreatment. Cardiac output (CO) during intravenous MIL infusion (0.25-0.75 μg/kg/min) between 1.5 and 2.5 hours after SAH induction was monitored with Doppler echocardiography. Magnetic resonance imaging (MRI)-continuous arterial spin labelling was used for quantitative cerebral blood flow (CBF) measurements. Neurobehavioral function was assessed daily by neurological score and open field test. DCI was analyzed 3 days later by determining infarction on MRI. Mild reduction of cardiac output (CO) and global cerebral blood flow (CBF) depression were notable early after SAH. MIL increased CO in a dose-dependent manner (P<.001), which was accompanied by improved hypoperfusion, incidence of DCI and functional recovery than Control (P<.05). The neuroprotective effects afforded by MIL or Control were attenuated by hypoxia-inducible factor (HIF) inhibition (P<.05). These results suggest that MIL improves acute hypoperfusion by its inotropic effect, leading to neurobehavioral improvement in mice after severe SAH, in which HIF may be acting as a critical mediator.

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“…Nevertheless, Takotsubo is often linked to physical or mental stress before the onset of illness [4]. Cases involving children has also been reported [8,9].…”

mentioning

confidence: 99%

The case of the women with the broken heart

Abelsson

2018

Disaster Emerg Med J

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Successful treatment of inverted Takotsubo cardiomyopathy after severe traumatic brain injury with milrinone after dobutamine failure

Cited by 30 publications

References 27 publications

Takotsubo Cardiomyopathy as a Neurocardiogenic Injury after Subarachnoid Hemorrhage: Hemodynamics and Fluid Management

Takotsubo Cardiomyopathy as a Neurocardiogenic Injury after Subarachnoid Hemorrhage: Hemodynamics and Fluid Management

Acute cardiac support with intravenous milrinone promotes recovery from early brain injury in a murine model of severe subarachnoid haemorrhage

The case of the women with the broken heart

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