Successful Treatment of Iron Deficiency Anemia with Ferric Carboxymaltose in an Elderly Patient with Multiple Comorbidities and COVID-19

Bassi, V.; Apuzzi, Valentina; Calderaro, Francesco; Piroddi, Massimo

doi:10.7759/cureus.16997

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Исследо вания, проведенные в мире во время пандемии COVID-19, показали, что при недостатке железа в организме снижается синтез молекул неспецифической иммунной защиты, фагоцитарной активности макрофагов и нейтрофилов, пролиферации Т-лимфоцитов и выработки В-лимфоцитами антител. Также увеличивается активность перекисного окисления липидов и повреждение тканей [16]. Отмечено, что пациенты с анемией во время коронавирусной инфекции испытывают более выраженную кислородную недостаточность и чаще нуждаются в инвазивной вентиляции легких.…”

Section: Rational Pharmacotherapyunclassified

Complex therapy recovered after infectious diseases

Vakulenko

2022

Medicinskij sovet

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Introduction. At the present time, the incidence of acute respiratory viral infections (ARVI) remains at a high level. Some patients who have undergone ARVI and COVID-19 have been disturbed by astheno-neurotic syndrome and chronic fatigue syndrome for quite a long time.Aim. To study the efficacy and safety dietary supplement treatment in the rehabilitation of patients recovered after acute respiratory viral infections.Materials and methods. We have examined 50 patients diagnosed with acute respiratory viral infections (38 people) and COVID-19 (12 people). Age of patients: from 25 years to 60 years old, average age 35 ± 11.84 years old. All patients were randomized into two study groups: the first group (25 people) received a biologically active food supplement and the second group (25 people) did not receive such complex. Сomplex was prescribed to the participants of the first group in amount of two capsules once a day. The course of therapy was 14 days. Before and after taking, all patients were assessed for shortness of breath on the MRC scale, depression on the Beck scale, chronic fatigue syndrome on the FAS scale, and the level of C-reactive protein (CRP) was assessed as well.Results. In the course of the observation, no significant difference between the groups was recorded in the dynamics of the state of assessment for dyspnea, depression and hemoglobin level. The average level of CRP before taking in the first group was 4.4 mg/l (from 0 to 22 mg/l), in the second – 3.8 mg/l (from 0 to 14 mg/l). When comparing the dynamics in the first group, there was more pronounced decrease in the level of CRP. In the first group, decrease in manifestations of pathological fatigue was revealed, characterized by decrease in FAS scores compared to the control group, where the number of scores, on the contrary, increased.Conclusions. Сomplex has a corrective effect on astheno-neurotic symptoms after suffering from acute respiratory viral infections or post-COVID syndrome.

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Section: Rational Pharmacotherapyunclassified

Complex therapy recovered after infectious diseases

Vakulenko

2022

Medicinskij sovet

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“…В период пандемии COVID 19 многочисленные мировые данные показали, что дефицит железа оказывает определенное влияние на гуморальное, клеточное и неспецифические звенья иммунитета, что играет важную роль в ответной реакции на патоген [4].…”

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Iron deficiency conditions prediction and prevention in children

Ilyenko,

Bogdanova,

Gureev

et al. 2023

Vestn. Ross. univ. družby nar., Ser. Med.

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The relevance of iron deficiency issues is due to the high frequency and tendency to steady growth, affecting the quality of life of the population. Pregnant, lactating women and young children are at high risk of developing iron deficiency conditions. Among pregnant women, a direct correlation was found between iron deficiency in the early stages of gestation and the pathological course of pregnancy and childbirth, lower indicators of physical, psychomotor development of children. Materials and methods. A prospective cohort study of 248 mother-child pairs was conducted. Pregnant, lactating women: the main group-women who received iron preparations during registration-106 persons, the comparison group-those who did not receive iron preparations-142. Inclusion criteria: absence of exacerbation of chronic pathology, allergic reactions, gastrointestinal pathology, infectious diseases. The women were examined at the end of the 3rd trimester and the postpartum period. Catamnestic observation was carried out for 248 children born to pregnant women. All children were observed with the informed consent of their parents. The duration of observation was up to a year. The children of the main group (106) and the comparison group (142) were singled out. Children of the main group on natural feeding (98) were divided into two subgroups. The first subgroup - 47 children whose mothers received iron preparations during lactation, the second subgroup - 51 children whose mothers did not receive iron subsidies. An assessment of the somatic status, a general clinical examination was carried out. Results and Discussion.Based on the data obtained using the statistical method of analysis, it was found that iron deficiency in the antenatal period significantly increased the frequency of premature birth, caused a deficiency of birth weight, heart disease, and led to a high frequency of viral infections in pregnant women. In newborns, from mothers who did not receive the iron preparation, a high frequency of latent iron deficiency (LID) and iron deficiency anemia (IDA) was noted. Newborns from the comparison group, according to the results of laboratory diagnostics, were treated with LID and IDA, however, lower indicators of physical development, NPR remained until 6 months. In the postnatal period, there was a direct correlation between the prophylactic intake of iron preparations by a nursing mother and the occurrence of latent iron deficiency and IDA in a child. Conclusion. The data obtained allow us to speak about the high effectiveness of preventive iron supplementation by a pregnant and lactating woman, to reduce the risk of pathological pregnancy and childbirth, affecting the indicators of physical and neuropsychic development (NPD) of a newborn and an infant. Even with the timely elimination of iron deficiency in a newborn, the delay in physical and NPR is noted up to 6 months. The analysis of the effect of iron deficiency in pregnant and nursing mothers on the course of the antenatal period, childbirth and the state of the child’s health dictates the need for prevention from the standpoint of a personalized approach.

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Successful Treatment of Iron Deficiency Anemia with Ferric Carboxymaltose in an Elderly Patient with Multiple Comorbidities and COVID-19

Abstract: Bassi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cited by 2 publications

References 15 publications

Complex therapy recovered after infectious diseases

Complex therapy recovered after infectious diseases

Iron deficiency conditions prediction and prevention in children

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