Successful treatment of Legionella micdadei (Pittsburgh pneumonia agent) pneumonia with erythromycin

Wing, Edward J.; Schafer, Frank; Pasculle, A. William

doi:10.1016/0002-9343(81)90376-4

Cited by 27 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on this information and the reported efficacy in L. pneumophila pneumonia, erythromycin, with or without rifampin, was successfully used for therapy of L. tnicdadei pneumonia (2,15,31).…”

mentioning

confidence: 99%

Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs

Pasculle¹,

Dowling²,

Frola³

et al. 1985

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Several antimicrobial agents were evaluated for activity against experimental Legionella micdadei pneumonia in guinea pigs. Erythromycin, rifampin, doxycycline, and sulfamethoxazole-trimethoprim produced significant reductions in mortality. Penicillin, cefazolin, cefoxitin, chloramphenicol, and gentamicin were not efficacious even though, at the doses administered, the peak concentrations of these agents in serum substantially exceeded their MICs for the test strain. It is suggested that the poor performance of the latter group of agents resulted from poor penetration into cells in which L. micdadei was multiplying.

show abstract

mentioning

confidence: 99%

Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs

Pasculle¹,

Dowling²,

Frola³

et al. 1985

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…no. 95, 1982) and in human disease (5,7,12,15,24). Thus, most microbiology laboratories should have the capability to determine the susceptibility of Legionella isolates to erythromycin and rifampin.…”

Section: Discussionmentioning

confidence: 99%

Disk diffusion antimicrobial susceptibility testing of members of the family Legionellaceae including erythromycin-resistant variants of Legionella micdadei

Dowling¹,

McDevitt²,

Pasculle³

1984

J Clin Microbiol

View full text Add to dashboard Cite

Disk diffusion antimicrobial susceptibility testing of members of the family Legionellaceae was accomplished on buffered charcoal yeast extract agar by allowing the bacteria to grow for 6 h before placement of the disks, followed by an additional 42-h incubation period before the inhibitory zones were measured. This system was standardized by comparing the zone sizes with the MICs for 20 antimicrobial agents of nine bacterial strains in five Legionella species and of 19 laboratory-derived, erythromycinresistant variants of Legionella micdadei. A high, linear correlation between zone size and MIC was found for erythromycin, trimethoprim, penicillin, ampicillin, carbenicillin, cephalothin, cefamandole, cefoxitin, moxalactam, chloramphenicol, vancomycin, and clindamycin. Disk susceptibility testing could be employed to screen Legionella isolates for resistance to any of these antimicrobial agents, of which only erythromycin is known to be efficacious in the treatment of legionellosis. With selected antibiotics, disk susceptibility patterns also appeared to accurately identify to the species level the legionellae. The range of the MICs of the legionellae for rifampin and the aminoglycosides was too small to determine whether the correlation of zone size with MIC was linear. However, laboratory-derived, high-level rifampin-resistant variants of L. micdadei demonstrated no inhibition zone around the rifampin disk, indicating that disk susceptibility testing would likely identify a rifampin-resistant clinical isolate. Of the antimicrobial agents tested, the only agents for which disk susceptibility testing was definitely not possible on buffered charcoal yeast extract agar were oxacillin, the tetracyclines, and the sulfonamides.

show abstract

“…9 Erythromycin also appears to be effective for the treatment of L. micdadei infection. 81,136 There is scant clinical information on the effectiveness of other agents. The combination of erythromycin and rifampin has been used successfully in compromised patients who failed therapy with erythromycin alone.…”

Section: Treatmentmentioning

confidence: 99%

Legionellosis in the Immunocompromised Patient

Ampel¹,

Wing²

1989

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Successful treatment of Legionella micdadei (Pittsburgh pneumonia agent) pneumonia with erythromycin

Cited by 27 publications

References 8 publications

Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs

Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs

Disk diffusion antimicrobial susceptibility testing of members of the family Legionellaceae including erythromycin-resistant variants of Legionella micdadei

Legionellosis in the Immunocompromised Patient

Contact Info

Product

Resources

About