Successful Treatment of Lipedematous Alopecia using Mycophenolate Mofetil

Cabrera, Raúl; Larrondo, Jorge; Whittle, Carolina; Castro, Álex; Gosch, Marianne

doi:10.2340/00015555-2114

Cited by 22 publications

(24 citation statements)

References 10 publications

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“…Only 2 reports mention a trichoscopic examination with the finding of multiple linear telangiectasias [12, 13]. Not present in our patient, this may be explained by the dark skin phototype, making erythema difficult to see or possibly because of the late stage of the disease.…”

Section: Discussionmentioning

confidence: 59%

Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature

et al. 2019

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A 66-year-old African woman suffered from a boggy thickening of the scalp in the frontoparietal area and the vertex accompanied by headache since infancy. In her thirties, she developed diffuse hair loss in the same area. Clinical and trichoscopic examination were unhelpful, but the histopathological and radiologic findings led to a diagnosis by demonstrating thick subcutaneous adipose tissue. First described in 1935 by Cornbleet [Arch Dermatol Syphilol. 1935; 32: 688], lipedematous scalp is a rare scalp disease marked by a soft thickening of the scalp. A similar clinicopathologic entity associated with nonscarring but permanent acquired alopecia was described in 1961 by Coskey et al. [Arch Dermatol. 1961 Oct; 84(4): 619–22] and termed lipedematous alopecia. In this article, we report a rare case of lipedematous alopecia with emphasis on a trichoscopic and histopathological description with review of the literature. Our case highlights the importance of palpation during the clinical examination. It remains to be determined whether this is actually a specific disease entity or a combination of 2 separate conditions. Symptomatic treatment is advisable given the lack of robust published data on treatment. Only 40 cases of lipedematous alopecia and 52 cases of lipedematous scalp have been published in the literature. Our case is the 93rd.

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Section: Discussionmentioning

confidence: 59%

Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature

et al. 2019

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“…Clinically it is detected by palpation of the scalp exhibiting a localized soft and non-tender swelling. Currently, there is no effective treatment for LS but surgical treatment and oral mycophenolate mofetil were documented to to be effective in LA as single case reports [1,2]. Here we report the first case in the medical literature of spontaneous resolution of lipedematous scalp in a patient whom we diagnosed and reported in 2004 to have Lipedematous scalp [3].…”

Section: Introductionmentioning

confidence: 83%

“…Yip et al [1], reported a successful treatment of LAS by surgical intervention with debulking and scalp reduction. Caberera et al [2], reported successful treatment of LS using mycophenolate mofetil. Our case is the first reported case of LS resolving spontaneously after 13 years which adds a significant clinical prognostic value to LS and LA.…”

Section: Open Accessmentioning

confidence: 99%

Spontaneous Resolution of Lipedematous Scalp after 13 Years

Bukhari¹,

Bagatadah²

2016

J Dermatol Plast Surg

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Lipedematous scalp and lipedematous alopecia is characterized by the localized accumulation of fatty tissue in the subcutaneous layer of the scalp. However, there is no effective treatment for this slowly progressing condition. Here we report the first case in the medical literature of spontaneous resolution of lipedematous scalp in a patient whom we diagnosed and reported in 2004 to have Lipedematous scalp.

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“…Attempts with corticosteroids local infiltration did not showed influence in reducing scalp thickening [9]. Recently, a case report described the use of mycophenolate mofetil with thickness reduction of scalp and improvement hair growth and density in lipedematous alopecia [10]. Additional studies about the pathophysiology, risk factors and mechanisms involved in its appearance are needed, so that specific therapeutic approach could be developed because of the rarity of this entity.…”

Section: Discussionmentioning

confidence: 99%

Lipedematous scalp in a patient with ankylosing spondylitis

Lang¹,

Keiserman²,

Duquia³

2016

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. IJCRI publishes

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Successful Treatment of Lipedematous Alopecia using Mycophenolate Mofetil

Cited by 22 publications

References 10 publications

Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature

Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature

Spontaneous Resolution of Lipedematous Scalp after 13 Years

Lipedematous scalp in a patient with ankylosing spondylitis

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