Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient

Higa, Tomitaka; Tasaka, Taizo; Kubo, Yasutaka; Nakagiri, Itsuhiro; Sano, Fumio; Matsuhashi, Yoshiko; Fukai, Yuta; Wada, Hideho; Tohyama, Kaoru; Sugihara, Takashi

doi:10.1080/00365540802287098

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…aureus meningitis should be treated with vancomycin until susceptibility testing is performed due to the increase of disease caused by methicillin-resistant strains (67). For treatment failures, linezolid and daptomycin can be considered, although the success of these agents has been described only in case reports (147,189).…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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SUMMARY The epidemiology of bacterial meningitis has changed as a result of the widespread use of conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the significant morbidity and mortality associated with bacterial meningitis, accurate information is necessary regarding the important etiological agents and populations at risk to ascertain public health measures and ensure appropriate management. In this review, we describe the changing epidemiology of bacterial meningitis in the United States and throughout the world by reviewing the global changes in etiological agents followed by specific microorganism data on the impact of the development and widespread use of conjugate vaccines. We provide recommendations for empirical antimicrobial and adjunctive treatments for clinical subgroups and review available laboratory methods in making the etiological diagnosis of bacterial meningitis. Finally, we summarize risk factors, clinical features, and microbiological diagnostics for the specific bacteria causing this disease.

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Section: Staphylococcus Aureusmentioning

confidence: 99%

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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“…Long‐term use of broad‐spectrum antimicrobial agents has been shown to improve uCBT outcomes . However, this strategy could potentially allow for unusual growth of microbes, including drug‐resistant strains .…”

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confidence: 99%

Relative incidences and outcomes of Clostridium difficile infection following transplantation of unrelated cord blood, unrelated bone marrow, and related peripheral blood in adult patients: a single institute study

Hosokawa

Takami

Tsuji

et al. 2014

Transplant Infectious Dis

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“…In literature we identified 14 case studies with detailed descriptions of 18 patients. [10][11][12][13][14][15][16][17][18][19][20][21][22][23] Causative organisms were S. pneumoniae in 3 of 18 patients (17%) and Listeria monocytogenes in 7 of 18 patients (39%). Enterococcus faecium was reported 3 of 18 patients (17%) and Staphylococcus aureus, Bacillus cereus, Elizabethkinkia meningoseptica and Stomatococcus mucilaginosus were all reported once.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Although the risk of infection after autologous and allogeneic HSCT has been well recognized, few studies have reported on the risk bacterial meningitis following HSCT. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] The number of allogeneic HSCT has increased in the Netherlands in the past decade from 175 in 2008 to 376 in 2012. 26 Furthermore, as survival following HSCT has substantially increased over the years, the number of patients at risk is growing fast.…”

Section: Introductionmentioning

confidence: 99%

Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study

Veen

Brouwer

Ende

et al. 2016

Bone Marrow Transplant

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We performed a nationwide prospective cohort study on the epidemiology and clinical features of community-acquired bacterial meningitis. Patients with a medical history of autologous or allogeneic hematopoietic stem cell transplantation (HSCT) were identified from the cohort performed from March 2006 to October 2014. Fourteen of 1449 episodes (1.0%) of bacterial meningitis occurred in patients with a history of HSCT. The incidence of bacterial meningitis in HSCT recipients was 40.4 per 100 000 patients per year (95% confidence interval (CI) 23.9-62.2), which is 30-fold (95% CI 18-51; P<0.001) higher compared with persons without HSCT. Incidence was higher in allogeneic HSCT compared with autologous HSCT (70.0 vs 15.8 per 100 000 patients per year). Causative organisms were Streptococcus pneumoniae in 11 patients, Neisseria meningitidis in two and Streptococcus mitis in one patient. Mortality was 3 of 14 (21%) and 6 of 11 (55%) survivors had sequelae. Nine of 11 patients (82%) with pneumococcal meningitis were infected with a serotype included in the 23-valent pneumococcal polysaccharide vaccine, of whom four developed meningitis despite vaccination. In conclusion, HSCT recipients have a substantially increased risk compared with the general population of acquiring bacterial meningitis, which is mostly due to S. pneumoniae, and disease is associated with high mortality and morbidity. Vaccination is important to prevent disease although vaccine failures did occur.

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Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient

Cited by 10 publications

References 14 publications

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Relative incidences and outcomes of Clostridium difficile infection following transplantation of unrelated cord blood, unrelated bone marrow, and related peripheral blood in adult patients: a single institute study

Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study

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