Successful Treatment of Metastatic Malignant Melanoma with Viscum album Extract (Iscador^® M)

Abstract

The use of low-dose Iscador as the sole postoperative modality for the adjuvant treatment of metastatic melanoma was extremely effective and very well tolerated in this patient. It achieved complete response and absence of all complaints.

Herbal Interactions with Anticancer Drugs: Mechanistic and Clinical Considerations

“…Polypeptides, including lectins and viscotoxins, are thought responsible for in vitro immune stimulant and tumor inhibition activity. However, the body of published reports suggesting efficacy for the treatment of cancer lacks welldesigned randomized trials and most of these data are only from small, uncontrolled trials and case reports [135][136][137][138][139][140]. A meta-analysis analyzed 11 of these clinical trials carried out before 1994 and showed no benefit from mistletoe [141].…”

Effects of selective cleavage of high-mannose-type glycans of Maackia amurensis leukoagglutinin on sialic acid-binding activity

“…The α2,3-sialic acid residue in receptors that are expressed on the surface of cancer cells is closely associated with the malignant phenotype and metastatic potential of many cancer cells [8,40,41]. The mistletoe lectins are known to bind glycoproteins containing the α2,3-sialic acid residue and are widely used to treat melanoma in Europe [42,43]. The α2,3-sialic acid-binding lectin MAL is also used to recognize these carbohydrates in cancer cells [40].…”

Disappearance of an Advanced Adenomatous Colon Polyp aer Intratumoural Injection with Viscum album (European mistletoe) Extract: a Case Report

“…However, disappearance of colon polyps is otherwise uncommon [19]. Remission of malignant tumours a er intratumoural injection of Viscum album extracts has been reported for cutaneous B-cell lymphoma, cutaneous squamous cell carcinoma, and malignant melanoma [6][7][8], but not yet for colon adenomas. e e ect is plausible given the known immune-stimulatory and cytotoxic e ects of Viscum album extract [12][13][14].…”

“…A recent randomized controlled tiral (RCT) showed survival bene t in advanced pancreatic cancer [5]. Case reports have documented durable tumour regression [6][7][8]. In colorectal cancer, studies have shown bene ts in terms of reduced cancer recurrence, survival in advanced cancer, and perioperative suppression of natural killer cells [9][10][11], but the speci c e ect of Viscum album extract on colon polyps has not been investigated.…”